Clinical characteristics, treatment patterns, and socio-economic burden of COPD in Bulgaria

Maria Kamusheva*, Maria Dimitrova, Job F. M. van Boven, Maarten J. Postma, Thys van der Molen, Janwillem W. H. Kocks, Konstantin Mitov, Miglena Doneva, Daniela Petrova, Ognyan Georgiev, Valentina Petkova, Guenka Petrova

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Background: While the impact of COPD in Western-Europe is known, data from Eastern-Europe is scarce. This study aimed to evaluate clinical characteristics, treatment patterns, and the socio-economic burden of COPD in Eastern-Europe, taking Bulgaria as a reference case.

Methods: A representative sample of Bulgarian patients with COPD was randomly chosen by pulmonologists, based on the following inclusion criteria: COPD diagnosis with at least 1 year of living with COPD, >= 40 years of age, and use of COPD medication. Patient characteristics, treatment, quality-of-life, healthcare resource use, and costs were systematically assessed.

Results: A total of 426 COPD patients were enrolled. Approximately 69% were male, 40% had occupational risk factors, 45% had severe and 11% had very severe COPD. Mean CAT scores were 13.80 (GOLD A), 21.80 (GOLD B), 17.35 (GOLD C), and 26.70 (GOLD D). Annual per-patient costs of healthcare utilization were Euro579. Yearly pharmacotherapy costs were Euro693. Indirect costs (reduced and lost work productivity) outnumbered direct costs three times.

Conclusions: Bulgaria has relatively high percentages of (very) severe COPD patients, resulting in considerable socio-economic burden. High smoking rates, occupational risk factors, air pollution, and a differential health system may be related to this finding. Eastern-European COPD strategies should focus on prevention, risk-factor awareness, and early detection.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalJournal of Medical Economics
Volume20
Issue number5
DOIs
Publication statusPublished - May-2017

Keywords

  • COPD
  • burden
  • costs
  • prevalence
  • epidemiology
  • OBSTRUCTIVE PULMONARY-DISEASE
  • WORKING AGE POPULATION
  • NEVER-SMOKERS
  • INTERNATIONAL SURVEY
  • PREVALENCE
  • IMPACT
  • SEVERITY
  • EUROPE
  • MORBIDITIES
  • COHORT

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