Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure

Yuya Matsue, Jozine M. ter Maaten, Joachim Struck, Marco Metra, Christopher M. O'Connor, Piotr Ponikowski, John R. Teerlink, Gad Cotter, Beth Davison, John G. Cleland, Michael M. Givertz, Daniel M. Bloomfield, Howard C. Dittrich, Dirk J. van Veldhuisen, Peter van der Meer, Kevin Damman, Adriaan A. Voors*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.

Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of I-131-Hippuran and I-125-iothalainate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalJOURNAL OF CARDIAC FAILURE
Volume23
Issue number3
DOIs
Publication statusPublished - Mar-2017

Keywords

  • Renal function
  • heart failure
  • prognosis
  • enkephalin
  • RECEPTOR ANTAGONIST ROLOFYLLINE
  • GLOMERULAR-FILTRATION-RATE
  • BLOOD UREA NITROGEN
  • ACUTE KIDNEY INJURY
  • RENAL-FUNCTION
  • MYOCARDIAL-INFARCTION
  • VOLUME OVERLOAD
  • MORTALITY
  • CONGESTION
  • PROTECT

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