Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure

Yuya Matsue; Jozine M. ter Maaten; Joachim Struck; Marco Metra; Christopher M. O'Connor; Piotr Ponikowski; John R. Teerlink; Gad Cotter; Beth Davison; John G. Cleland; Michael M. Givertz; Daniel M. Bloomfield; Howard C. Dittrich; Dirk J. van Veldhuisen; Peter van der Meer; Kevin Damman; Adriaan A. Voors

doi:10.1016/j.cardfail.2016.09.007

Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure

Yuya Matsue, Jozine M. ter Maaten, Joachim Struck, Marco Metra, Christopher M. O'Connor, Piotr Ponikowski, John R. Teerlink, Gad Cotter, Beth Davison, John G. Cleland, Michael M. Givertz, Daniel M. Bloomfield, Howard C. Dittrich, Dirk J. van Veldhuisen, Peter van der Meer, Kevin Damman, Adriaan A. Voors^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.

Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of I-131-Hippuran and I-125-iothalainate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P

Original language	English
Pages (from-to)	231-239
Number of pages	9
Journal	JOURNAL OF CARDIAC FAILURE
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.cardfail.2016.09.007
Publication status	Published - Mar-2017

Keywords

Renal function
heart failure
prognosis
enkephalin
RECEPTOR ANTAGONIST ROLOFYLLINE
GLOMERULAR-FILTRATION-RATE
BLOOD UREA NITROGEN
ACUTE KIDNEY INJURY
RENAL-FUNCTION
MYOCARDIAL-INFARCTION
VOLUME OVERLOAD
MORTALITY
CONGESTION
PROTECT

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Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure
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Matsue, Y., ter Maaten, J. M., Struck, J., Metra, M., O'Connor, C. M., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G., Givertz, M. M., Bloomfield, D. M., Dittrich, H. C., van Veldhuisen, D. J., van der Meer, P., Damman, K., & Voors, A. A. (2017). Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure. JOURNAL OF CARDIAC FAILURE, 23(3), 231-239. https://doi.org/10.1016/j.cardfail.2016.09.007

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abstract = "Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of I-131-Hippuran and I-125-iothalainate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P",

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author = "Yuya Matsue and {ter Maaten}, {Jozine M.} and Joachim Struck and Marco Metra and O'Connor, {Christopher M.} and Piotr Ponikowski and Teerlink, {John R.} and Gad Cotter and Beth Davison and Cleland, {John G.} and Givertz, {Michael M.} and Bloomfield, {Daniel M.} and Dittrich, {Howard C.} and {van Veldhuisen}, {Dirk J.} and {van der Meer}, Peter and Kevin Damman and Voors, {Adriaan A.}",

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Matsue, Y, ter Maaten, JM, Struck, J, Metra, M, O'Connor, CM, Ponikowski, P, Teerlink, JR, Cotter, G, Davison, B, Cleland, JG, Givertz, MM, Bloomfield, DM, Dittrich, HC, van Veldhuisen, DJ , van der Meer, P , Damman, K & Voors, AA 2017, 'Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure', JOURNAL OF CARDIAC FAILURE, vol. 23, no. 3, pp. 231-239. https://doi.org/10.1016/j.cardfail.2016.09.007

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T1 - Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure

AU - Matsue, Yuya

AU - ter Maaten, Jozine M.

AU - Struck, Joachim

AU - Metra, Marco

AU - O'Connor, Christopher M.

AU - Ponikowski, Piotr

AU - Teerlink, John R.

AU - Cotter, Gad

AU - Davison, Beth

AU - Cleland, John G.

AU - Givertz, Michael M.

AU - Bloomfield, Daniel M.

AU - Dittrich, Howard C.

AU - van Veldhuisen, Dirk J.

AU - van der Meer, Peter

AU - Damman, Kevin

AU - Voors, Adriaan A.

PY - 2017/3

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N2 - Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of I-131-Hippuran and I-125-iothalainate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P

AB - Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure.Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements, including renal blood flow (RBF) and glomerular filtration rate (GFR) with the use of I-131-Hippuran and I-125-iothalainate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P

KW - Renal function

KW - heart failure

KW - prognosis

KW - enkephalin

KW - RECEPTOR ANTAGONIST ROLOFYLLINE

KW - GLOMERULAR-FILTRATION-RATE

KW - BLOOD UREA NITROGEN

KW - ACUTE KIDNEY INJURY

KW - RENAL-FUNCTION

KW - MYOCARDIAL-INFARCTION

KW - VOLUME OVERLOAD

KW - MORTALITY

KW - CONGESTION

KW - PROTECT

U2 - 10.1016/j.cardfail.2016.09.007

DO - 10.1016/j.cardfail.2016.09.007

M3 - Article

VL - 23

SP - 231

EP - 239

JO - JOURNAL OF CARDIAC FAILURE

JF - JOURNAL OF CARDIAC FAILURE

SN - 1071-9164

IS - 3

ER -