Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Robin E. A. Tjon Pian Gi; Michel R. M.  San Giorgi; Lorian Slagter-Menkema; Bettien M. van Hemel; Bernard F. A. M. van der Laan; Edwin R. van den Heuvel; Frederik G. Dikkers; Ed M. D. Schuuring

doi:10.1002/hed.23808

Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Robin E. A. Tjon Pian Gi, Michel R. M. San Giorgi, Lorian Slagter-Menkema, Bettien M. van Hemel, Bernard F. A. M. van der Laan, Edwin R. van den Heuvel, Frederik G. Dikkers^*, Ed M. D. Schuuring

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.

Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.

Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (

Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	1625-1632
Number of pages	8
Journal	Head and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume	37
Issue number	11
DOIs	https://doi.org/10.1002/hed.23808
Publication status	Published - Nov-2015

Keywords

human papillomavirus
HPV6
HPV11
HPV
recurrent respiratory papillomatosis
clinical course
SQUAMOUS-CELL CARCINOMA
MALIGNANT-TRANSFORMATION
RISK-FACTORS
ONSET
POPULATION
IDENTIFICATION
PREVALENCE
PREDICTORS
EXPERIENCE

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Tjon Pian Gi, R. E. A., San Giorgi, M. R. M., Slagter-Menkema, L., van Hemel, B. M., van der Laan, B. F. A. M., van den Heuvel, E. R., Dikkers, F. G., & Schuuring, E. M. D. (2015). Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, 37(11), 1625-1632. https://doi.org/10.1002/hed.23808

Tjon Pian Gi, Robin E. A. ; San Giorgi, Michel R. M. ; Slagter-Menkema, Lorian ; van Hemel, Bettien M. ; van der Laan, Bernard F. A. M. ; van den Heuvel, Edwin R. ; Dikkers, Frederik G. ; Schuuring, Ed M. D. / Clinical course of recurrent respiratory papillomatosis : Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 2015 ; Vol. 37, No. 11. pp. 1625-1632.

@article{6559c16f8d0a4af78248ed72dc74bb4d,

title = "Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11",

abstract = "Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.",

keywords = "human papillomavirus, HPV6, HPV11, HPV, recurrent respiratory papillomatosis, clinical course, SQUAMOUS-CELL CARCINOMA, MALIGNANT-TRANSFORMATION, RISK-FACTORS, ONSET, POPULATION, IDENTIFICATION, PREVALENCE, PREDICTORS, EXPERIENCE",

author = "{Tjon Pian Gi}, {Robin E. A.} and {San Giorgi}, {Michel R. M.} and Lorian Slagter-Menkema and {van Hemel}, {Bettien M.} and {van der Laan}, {Bernard F. A. M.} and {van den Heuvel}, {Edwin R.} and Dikkers, {Frederik G.} and Schuuring, {Ed M. D.}",

note = "Copyright {\textcopyright} 2014 Wiley Periodicals, Inc.",

year = "2015",

month = nov,

doi = "10.1002/hed.23808",

language = "English",

volume = "37",

pages = "1625--1632",

journal = "Head and Neck: Journal of the Sciences and Specialties of the Head and Neck",

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Tjon Pian Gi, REA, San Giorgi, MRM, Slagter-Menkema, L, van Hemel, BM , van der Laan, BFAM, van den Heuvel, ER, Dikkers, FG & Schuuring, EMD 2015, 'Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11', Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, vol. 37, no. 11, pp. 1625-1632. https://doi.org/10.1002/hed.23808

Clinical course of recurrent respiratory papillomatosis : Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. / Tjon Pian Gi, Robin E. A.; San Giorgi, Michel R. M. ; Slagter-Menkema, Lorian; van Hemel, Bettien M.; van der Laan, Bernard F. A. M.; van den Heuvel, Edwin R.; Dikkers, Frederik G.; Schuuring, Ed M. D.

In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, Vol. 37, No. 11, 11.2015, p. 1625-1632.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Clinical course of recurrent respiratory papillomatosis

T2 - Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

AU - Tjon Pian Gi, Robin E. A.

AU - San Giorgi, Michel R. M.

AU - Slagter-Menkema, Lorian

AU - van Hemel, Bettien M.

AU - van der Laan, Bernard F. A. M.

AU - van den Heuvel, Edwin R.

AU - Dikkers, Frederik G.

AU - Schuuring, Ed M. D.

PY - 2015/11

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N2 - Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.

AB - Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.

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KW - SQUAMOUS-CELL CARCINOMA

KW - MALIGNANT-TRANSFORMATION

KW - RISK-FACTORS

KW - ONSET

KW - POPULATION

KW - IDENTIFICATION

KW - PREVALENCE

KW - PREDICTORS

KW - EXPERIENCE

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DO - 10.1002/hed.23808

M3 - Article

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JF - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

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Tjon Pian Gi REA, San Giorgi MRM, Slagter-Menkema L, van Hemel BM , van der Laan BFAM, van den Heuvel ER et al. Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 2015 Nov;37(11):1625-1632. https://doi.org/10.1002/hed.23808