TY - JOUR
T1 - Clinical course of recurrent respiratory papillomatosis
T2 - Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11
AU - Tjon Pian Gi, Robin E. A.
AU - San Giorgi, Michel R. M.
AU - Slagter-Menkema, Lorian
AU - van Hemel, Bettien M.
AU - van der Laan, Bernard F. A. M.
AU - van den Heuvel, Edwin R.
AU - Dikkers, Frederik G.
AU - Schuuring, Ed M. D.
N1 - Copyright © 2014 Wiley Periodicals, Inc.
PY - 2015/11
Y1 - 2015/11
N2 - Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.
AB - Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.
KW - human papillomavirus
KW - HPV6
KW - HPV11
KW - HPV
KW - recurrent respiratory papillomatosis
KW - clinical course
KW - SQUAMOUS-CELL CARCINOMA
KW - MALIGNANT-TRANSFORMATION
KW - RISK-FACTORS
KW - ONSET
KW - POPULATION
KW - IDENTIFICATION
KW - PREVALENCE
KW - PREDICTORS
KW - EXPERIENCE
U2 - 10.1002/hed.23808
DO - 10.1002/hed.23808
M3 - Article
C2 - 24955561
VL - 37
SP - 1625
EP - 1632
JO - Journal of the Sciences and Specialties of the Head and Neck
JF - Journal of the Sciences and Specialties of the Head and Neck
SN - 1043-3074
IS - 11
ER -