Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study

EG Winkel*, S Roldan, AJ Van Winkelhoff, D Herrera, M Sanz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

125 Citations (Scopus)

Abstract

Objectives: The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.

Material and methods: Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score >1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC) >170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI) > 4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.

Results: Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p <0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p <0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p <0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p <0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.

Conclusions: In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalJournal of Clinical Periodontology
Volume30
Issue number4
Publication statusPublished - Apr-2003

Keywords

  • halitosis
  • volatile sulfur compounds
  • chlorhexidine
  • cetylpyridinium chloride
  • zinc-lactate
  • mouthrinse
  • double-blind placebo-controlled study
  • VOLATILE SULFUR-COMPOUNDS
  • SALIVARY-GLAND HYPOFUNCTION
  • OIL-WATER MOUTHRINSE
  • SULFIDE MONITOR
  • FLUID BALANCE
  • BREATH-ODOR
  • MALODOR
  • REDUCTION
  • PERIODONTITIS
  • CONSUMPTION

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