Clinical implications of vitamin B12 as redox-active cofactor

Annette K. Offringa, Arno R. Bourgonje, Matthew S. Schrier, Richard C. Deth, Harry van Goor*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Vitamin B12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B12 may be clinically used to reduce oxidative stress and preserve cofactor functions.
Original languageEnglish
Number of pages4
JournalTRENDS IN MOLECULAR MEDICINE
DOIs
Publication statusE-pub ahead of print - 23-Jul-2021

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