Clinical relevance of advanced glycation endproducts for vascular surgery

R. Meerwaldt, M. G. van der Vaart, G. M. van Dam, R. A. Tio, J. -L. Hillebrands, A. J. Smit, C. J. Zeebregts*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Atherosclerosis is the main contributor to cardiovascular disease and leads to intimal plaque formation, which may progress to plaque rupture with subsequent thromboembolic events and/or occlusion of the arterial lumen. There is increasing evidence that the development or progression of atherosclerosis is associated with advanced glycation endproducts (AGEs). AGEs are a heterogeneous group of compounds formed by the non-enzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids. An increased understanding of the mechanisms of formation and interaction of AGEs has allowed the development of several potential anti-AGE strategies. This review summarizes AGE. formation and biochemistry, the pathogeneic role of AGEs in cardiovascular disease, anti-AGE therapies and clinical relevance to vascular surgery. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume36
Issue number2
DOIs
Publication statusPublished - Aug-2008

Keywords

  • advanced glycation
  • vascular surgery
  • plaque vulnerability
  • patency
  • diabetic foot
  • GLYCOXIDATION END-PRODUCTS
  • TYPE-2 DIABETIC-PATIENTS
  • CORONARY-ARTERY-DISEASE
  • OXIDATIVE STRESS
  • MAILLARD REACTION
  • SKIN AUTOFLUORESCENCE
  • HEMODIALYSIS-PATIENTS
  • SERUM-LEVELS
  • ATHEROSCLEROTIC PLAQUES
  • NEOINTIMAL FORMATION

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