Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid-organ transplant recipients: a retrospective, multicentre cohort study

C. Ferrandiz-Pulido*, A. Gomez-Tomas, B. Llombart, D. Mendoza, J. Marcoval, S. Piaserico, C. Baykal, J. N. Bouwes-Bavinck, E. Racz, J. Kanitakis, C. A. Harwood, P. Cetkovska, A. Geusau, Veronique Del Marmol, E. Masferrer, C. Orte Cano, J. Ricar, W. R. de Oliveira, R. Salido-Vallejo, E. DucrouxM. A. Gkini, J. A. Lopez-Guerrero, H. Kutzner, W. Kempf, D. Seckin

*Corresponding author for this work

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    Abstract

    Background The proportion of Merkel cell carcinomas (MCCs) in solid-organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV-status and identify factors associated with tumour outcomes. Methods Retrospective, international, cohort-study. MCPyV-status was investigated by immunohistochemistry and polymerase chain reaction. Results A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P < 0.001). Thirty-three percent of SOTR MCCs were MCPyV-positive vs. 91% of immunocompetent MCCs (P = 0.001). Solid-organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3.35 [1.57-7.14], P = 0.002), MCC-specific mortality (SHR: 2.55 [1.07-6.06], P = 0.034) and overall mortality (HR: 3.26 [1.54-6.9], P = 0.002). MCPyV-positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4.3 [1.5-13], P = 0.008 and SHR: 3.6 [1.1-12], P = 0.032 respectively) in SOTR. Limitations Retrospective design and heterogeneity of SOTR cohort. Conclusions MCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression.

    Original languageEnglish
    Number of pages11
    JournalJournal of the European Academy of Dermatology and Venereology
    DOIs
    Publication statusE-pub ahead of print - 24-May-2022

    Keywords

    • POLYOMAVIRUS INFECTION
    • SURVIVAL
    • ASSOCIATION
    • RECURRENCE
    • CANCER
    • TUMOR
    • LIVER
    • HEART

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