Closed loop controlled administration of propofol using bispectral analysis

E Mortier; M Struys; T De Smet; L Versichelen; G Rolly

Closed loop controlled administration of propofol using bispectral analysis

E Mortier^*, M Struys, T De Smet, L Versichelen, G Rolly

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

147 Citations (Scopus)

Abstract

Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.

Original language	English
Pages (from-to)	749-754
Number of pages	6
Journal	Anaesthesia
Volume	53
Issue number	8
Publication status	Published - Aug-1998
Externally published	Yes

Keywords

anaesthetics, intravenous, propofol
measurement techniques, bispectral analysis
SKIN INCISION
ANESTHESIA
DEPTH
EEG
ELECTROENCEPHALOGRAM
FENTANYL
ISOFLURANE
MIDAZOLAM
TOLERANCE
INFUSION

Handle.net

Persistent link

Cite this

@article{6c730f55da77439f81764202a0c5e84e,

title = "Closed loop controlled administration of propofol using bispectral analysis",

abstract = "Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.",

keywords = "anaesthetics, intravenous, propofol, measurement techniques, bispectral analysis, SKIN INCISION, ANESTHESIA, DEPTH, EEG, ELECTROENCEPHALOGRAM, FENTANYL, ISOFLURANE, MIDAZOLAM, TOLERANCE, INFUSION",

author = "E Mortier and M Struys and {De Smet}, T and L Versichelen and G Rolly",

year = "1998",

month = aug,

language = "English",

volume = "53",

pages = "749--754",

journal = "Anaesthesia",

issn = "0003-2409",

publisher = "Wiley",

number = "8",

}

TY - JOUR

T1 - Closed loop controlled administration of propofol using bispectral analysis

AU - Mortier, E

AU - Struys, M

AU - De Smet, T

AU - Versichelen, L

AU - Rolly, G

PY - 1998/8

Y1 - 1998/8

N2 - Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.

AB - Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.

KW - anaesthetics, intravenous, propofol

KW - measurement techniques, bispectral analysis

KW - SKIN INCISION

KW - ANESTHESIA

KW - DEPTH

KW - EEG

KW - ELECTROENCEPHALOGRAM

KW - FENTANYL

KW - ISOFLURANE

KW - MIDAZOLAM

KW - TOLERANCE

KW - INFUSION

M3 - Article

SN - 0003-2409

VL - 53

SP - 749

EP - 754

JO - Anaesthesia

JF - Anaesthesia

IS - 8

ER -

Closed loop controlled administration of propofol using bispectral analysis

Abstract

Keywords

Handle.net

Fingerprint

Cite this