Clustering on Membranes: Fluctuations and More

Ludger Johannes*, Weria Pezeshkian, John H. Ipsen, Julian C. Shillcock

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)

Abstract

Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.

Original languageEnglish
Pages (from-to)405-415
Number of pages11
JournalTrends in Cell Biology
Volume28
Issue number5
DOIs
Publication statusPublished - May-2018
Externally publishedYes

Keywords

  • CURVATURE-MEDIATED INTERACTIONS
  • CELL-MEMBRANE
  • PLASMA-MEMBRANES
  • BIOLOGICAL-MEMBRANES
  • ANCHORED PROTEINS
  • PHASE-SEPARATION
  • LIPID-BILAYERS
  • INDUCED FORCES
  • ORGANIZATION
  • RAFTS

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