Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer type (sDAT). Previous studies have shown that Co-57 Single photon emission computed tomography (SPECT) is able to visualize inflammatory lesions, probably by means of the final common pathway of Ca2+ homeostasis disturbance in both neuronal degeneration and inflammation. The aims of this study were: (1) to detect Co-57 SPECT changes in sDAT patients; (2) to correlate these findings with those of conventional neuroimaging techniques and neuropsychological testing (NPT); and (3) to compare Co-57 SPECT findings in sDAT patients with those in other types of dementia. Six patients suffering from probable sDAT were included and compared with four patients suffering from other types of dementia. All patients had a magnetic resonance imaging (MRI) scan, NPT, Co-57 and Tc-99m-ethyl cysteinate dimer (ECD) SPECT scan. Perfusion SPECT images were semiquantitatively evaluated by comparison with an age-matched normal database, while Co-57 SPECT scans were assessed qualitatively. MRI and Tc-99m-ECD SPECT scans yielded conclusive results with regard to the exclusion of other pathologies and the confirmation of the diagnosis. Using visual analysis, Co-57 SPECT scans were unable to show any regional raised uptake, irrespective of the disorder, depth or extent of the perfusion defects, presence of atrophy on MRI or the results of NPT. ((C) 2001 Lippincott Williams & Wilkins).
|Number of pages||7|
|Journal||Nuclear Medicine Communications|
|Publication status||Published - Jun-2001|
- Co-57-senile dementia of the Alzheimer type
- CEREBRAL BLOOD-FLOW
- KAINATE RECEPTORS
- VASCULAR DEMENTIA