Co-crystal of suberic acid and 1,2-bis(4-pyridyl)ethane: A new case of packing polymorphism

Maria A. Susano, Pablo Martin-Ramos, Teresa M. R. Maria, Steven Folkersma, Laura C. J. Pereira, Manuela Ramos Silva*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)
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    Abstract

    The polymorphic behaviour of a co-crystal composed of neutral suberic acid and 1,2-bis(4-pyridyl)ethane is reported. A multidisciplinary approach has been employed, using thermal analysis methods (differential scanning calorimetry and polarized light thermomicroscopy), spectroscopic methods (infrared spectroscopy) and X-ray single crystal and powder diffraction. Two new polymorphs, Land III; have been identified, and for one of them the crystal structure has been elucidated and compared to that of a known polymorph, form II, showing that the assembling of the molecules in chains via H-bonds is a common feature of both polymorphs. Polymorph II, obtained by crystallization from an aqueous or ethanol solution or by grinding, undergoes a solid-solid transition to polyniorph I, which melts at 180.5 degrees C. Upon cooling from the melt, polymorph I is obtained, and a solid-solid transformation also occurs, to poly morph III'. Polymorph III was obtained serendipitously in an attempt to prepare a Nd(III) complex. The relative stability of the three polymorphic forms was established. (C) 2017 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)76-83
    Number of pages8
    JournalJournal of Molecular Structure
    Volume1147
    DOIs
    Publication statusPublished - 5-Nov-2017

    Keywords

    • Co-crystal
    • Phase transition
    • Polymorph
    • Thermal analysis
    • X-ray diffraction
    • THERMODYNAMIC RULES
    • MOLECULAR-CRYSTALS
    • CARBOXYLIC-ACIDS
    • COCRYSTALS
    • PHARMACEUTICALS
    • ABSORPTION
    • COMPLEXES
    • ADDUCTS

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