TY - JOUR
T1 - Co-occurrence of chronic kidney disease and glaucoma
T2 - Epidemiology and etiological mechanisms
AU - Liu, Wei
AU - Guo, Ruru
AU - Huang, Dandan
AU - Ji, Jian
AU - Gansevoort, Ron T.
AU - Snieder, Harold
AU - Jansonius, Nomdo M.
N1 - Funding Information:
The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article. This work was supported by grants from the Open Project of Tianjin Key Laboratory of Retinal Functions and Diseases ( 2020tjswmq003 ), Youth Special Fund of Clinical Research of Tianjin Medical University Eye Hospital ( 2020QN02 ), Tianjin Key Medical Discipline (Specialty) Construction Project ( TJYXZDXK-037A ) and by the University of Groningen Abel Tasman Talent Program (University Medical Center Groningen/Tianjin Medical University). These funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2022 The Authors
PY - 2022/9/8
Y1 - 2022/9/8
N2 - As the histology, physiology, and pathophysiology of eyes and kidneys show substantial overlap, it has been suggested that eye and kidney diseases, such as glaucoma and chronic kidney disease (CKD), may be closely interlinked. We review the relationship between CKD and various subtypes of glaucoma, including primary open-angle glaucoma, primary angle- closure glaucoma, normal tension glaucoma, pseudoexfoliation syndrome, and several glaucoma endophenotypes. We also discuss the underlying pathogenic mechanisms and common risk factors for CKD and glaucoma, including atherosclerosis, the renin-angiotensin system, genes and genetic polymorphisms, vitamin D deficiency, and erythropoietin. The prevalence of glaucoma appears elevated in CKD patients, and vice versa, and the literature points to many intriguing associations; however, the associations are not always confirmed, and sometimes apparently opposite observations are reported. Glaucoma and CKD are complex diseases, and their mutual influence is only partially understood.
AB - As the histology, physiology, and pathophysiology of eyes and kidneys show substantial overlap, it has been suggested that eye and kidney diseases, such as glaucoma and chronic kidney disease (CKD), may be closely interlinked. We review the relationship between CKD and various subtypes of glaucoma, including primary open-angle glaucoma, primary angle- closure glaucoma, normal tension glaucoma, pseudoexfoliation syndrome, and several glaucoma endophenotypes. We also discuss the underlying pathogenic mechanisms and common risk factors for CKD and glaucoma, including atherosclerosis, the renin-angiotensin system, genes and genetic polymorphisms, vitamin D deficiency, and erythropoietin. The prevalence of glaucoma appears elevated in CKD patients, and vice versa, and the literature points to many intriguing associations; however, the associations are not always confirmed, and sometimes apparently opposite observations are reported. Glaucoma and CKD are complex diseases, and their mutual influence is only partially understood.
KW - Chronic kidney disease
KW - Estimated glomerular filtration rate
KW - Glaucoma
KW - Primary open-angle glaucoma
KW - Uric acid
U2 - 10.1016/j.survophthal.2022.09.001
DO - 10.1016/j.survophthal.2022.09.001
M3 - Review article
C2 - 36088997
AN - SCOPUS:85139027879
SN - 0039-6257
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
ER -