Cognitive Adaptation under Stress: A Case for the Mineralocorticoid Receptor

Susanne Vogel, Gullen Fernandez, Marian Joels, Lars Schwabe*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

111 Citations (Scopus)

Abstract

Corticosteroid hormones, released during stressful encounters, have profound and far-reaching effects on cognition. They are often thought to accomplish these effects primarily via glucocorticoid receptors (GR), but recent findings from rodent and human studies argue for an additional, critical role of the mineralocorticoid receptor (MR) in cognitive changes in response to stress. We propose that the MR initiates rapid changes in the recruitment of specific neural systems, inducing a shift towards cognitively less-demanding processing and allowing a quick and adequate response to the situation. In combination with slower and longer-lasting actions mediated by GR, this shift leads to optimal coping with the ongoing stressful event.

Original languageEnglish
Pages (from-to)192-203
Number of pages12
JournalTrends in Cognitive Sciences
Volume20
Issue number3
DOIs
Publication statusPublished - Mar-2016
Externally publishedYes

Keywords

  • MULTIPLE MEMORY-SYSTEMS
  • LONG-TERM POTENTIATION
  • BORDERLINE PERSONALITY-DISORDER
  • MAJOR DEPRESSIVE DISORDER
  • DAY-OLD CHICKS
  • GLUCOCORTICOID-RECEPTORS
  • INDIVIDUAL-DIFFERENCES
  • INDUCED ENHANCEMENT
  • PREFRONTAL CORTEX
  • SPATIAL MEMORY

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