Abstract
Background. Several prospective longitudinal studies have suggested that somatic/affective depressive symptoms, but not cognitive/affective depressive symptoms, are related to prognosis in patients with heart disease, but findings have been inconsistent. The aim of this study was to investigate the association of cognitive/affective and somatic/affective symptoms of depression with cardiovascular prognosis in patients with heart disease using a meta-analytic perspective.
Method. A systematic search was performed in PubMed, EMBASE and PsycInfo. Thirteen prospective studies on symptom dimensions of depression and cardiovascular prognosis fulfilled the inclusion criteria, providing data on a total of 11 128 subjects. The risk estimates for each dimension of depressive symptoms, demographic and methodological variables were extracted from the included articles.
Results. In least-adjusted analyses, both the somatic/affective [hazard ratio (HR) 1.30, 95% confidence interval (CI) 1.19-1.41, p
Conclusions. Somatic/affective depressive symptoms were more strongly and consistently associated with mortality and cardiovascular events in patients with heart disease compared with cognitive/affective symptoms. Future research should focus on the mechanisms by which somatic/affective depressive symptoms may affect cardiovascular prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 2689-2703 |
| Number of pages | 15 |
| Journal | Psychological Medicine |
| Volume | 44 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - Oct-2014 |
Keywords
- Depression
- heart disease
- meta-analysis
- symptom dimension
- ACUTE MYOCARDIAL-INFARCTION
- CORONARY-ARTERY-DISEASE
- CARDIAC PROGNOSIS
- SOMATIC SYMPTOMS
- HEALTH-STATUS
- INVENTORY-II
- RISK-FACTOR
- MORTALITY
- DIMENSIONS
- EVENTS