Colonic delivery of plymyxin E and four quinolones for flora suppression

Joris Jan Maria van Saene

Research output: ThesisThesis fully internal (DIV)

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The high doses of antimicrobials to be taken orally are frequently associated with side-effects including headache, sickness, nausea and/or vomiting, stomachache, abdominal pain, gastro-intestinal disturbances and diarrhoea. Moreover, a systemic antibiotic concentration following absorption is theoretically not required for these two goals. The high frequency of these side-effects often leads to a poor compliance, at least in the conscious patient. The major aim of this study is the development of an oral administration form that is followed by an identical (or even better or more efficient) microbial and endotoxin suppression associated with a substantial reduction or absence of side-effects.... Zie: Summary
Original languageEnglish
QualificationDoctor of Philosophy
  • Lerk, Coenraad, Supervisor
Print ISBNs9090036911
Publication statusPublished - 1990


  • Proefschriften (vorm)
  • Antibacterièele middelen, Polymyxine E,
  • Chinolonen, Orale toediening, Dikke darm, Drug targeting
  • farmacologie (geneeskunde)

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