Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

M. W. M. D. Lutgens; B. Oldenburg; P. D. Siersema; A. A. van Bodegraven; G. Dijkstra; D. W. Hommes; D. J. de Jong; P. C. F. Stokkers; C. J. van der Woude; F. P. Vleggaar; ICC

doi:10.1038/sj.bjc.6605359

Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

M. W. M. D. Lutgens
, B. Oldenburg
, P. D. Siersema
, A. A. van Bodegraven
, G. Dijkstra
, D. W. Hommes
, D. J. de Jong
, P. C. F. Stokkers
, C. J. van der Woude
, F. P. Vleggaar^*
, ICC

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.

METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.

RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).

CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.

British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.com

Original language	English
Pages (from-to)	1671-1675
Number of pages	5
Journal	British Jounal of Cancer
Volume	101
Issue number	10
DOIs	https://doi.org/10.1038/sj.bjc.6605359
Publication status	Published - 10-Nov-2009

Keywords

inflammatory bowel disease
colorectal cancer
surveillance
survival
tumour stage
IBD
CRC
ULCERATIVE-COLITIS
CROHNS COLITIS
POPULATION
METAANALYSIS
NETHERLANDS
GUIDELINES
CARCINOMA
MORTALITY
PROGRAM
COHORT

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Parel Infammatory Bowel Disease (IBD)
Dijkstra, G. (Creator), F.M., T. (Other), Lowenberg, M. (Creator), Bosma, C. (Data Manager) & Terpstra, F. (Data Manager), University of Groningen, 2017
https://1000ibd.org/menu/main/background
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Lutgens, M. W. M. D., Oldenburg, B., Siersema, P. D., van Bodegraven, A. A., Dijkstra, G., Hommes, D. W., de Jong, D. J., Stokkers, P. C. F., van der Woude, C. J., Vleggaar, F. P., & ICC (2009). Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease. British Jounal of Cancer, 101(10), 1671-1675. https://doi.org/10.1038/sj.bjc.6605359

@article{eca043e0e60f4b2aa5d005253c0093e7,

title = "Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease",

abstract = "BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100\% compared with 74\% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK",

keywords = "inflammatory bowel disease, colorectal cancer, surveillance, survival, tumour stage, IBD, CRC, ULCERATIVE-COLITIS, CROHNS COLITIS, POPULATION, METAANALYSIS, NETHERLANDS, GUIDELINES, CARCINOMA, MORTALITY, PROGRAM, COHORT",

author = "Lutgens, \{M. W. M. D.\} and B. Oldenburg and Siersema, \{P. D.\} and \{van Bodegraven\}, \{A. A.\} and G. Dijkstra and Hommes, \{D. W.\} and \{de Jong\}, \{D. J.\} and Stokkers, \{P. C. F.\} and \{van der Woude\}, \{C. J.\} and Vleggaar, \{F. P.\} and ICC",

year = "2009",

month = nov,

day = "10",

doi = "10.1038/sj.bjc.6605359",

language = "English",

volume = "101",

pages = "1671--1675",

journal = "British Jounal of Cancer",

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T1 - Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

AU - Lutgens, M. W. M. D.

AU - Oldenburg, B.

AU - Siersema, P. D.

AU - van Bodegraven, A. A.

AU - Dijkstra, G.

AU - Hommes, D. W.

AU - de Jong, D. J.

AU - Stokkers, P. C. F.

AU - van der Woude, C. J.

AU - Vleggaar, F. P.

AU - ICC

PY - 2009/11/10

Y1 - 2009/11/10

N2 - BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK

AB - BACKGROUND: Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.METHOD: The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.RESULTS: A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P = 0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P = 0.047). In addition, more early tumour stages were found in the surveillance group (P = 0.004).CONCLUSIONS: These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.British Journal of Cancer (2009) 101, 1671-1675. doi: 10.1038/sj.bjc.6605359 www.bjcancer.comPublished online 13 October 2009 (C) 2009 Cancer Research UK

KW - inflammatory bowel disease

KW - colorectal cancer

KW - surveillance

KW - survival

KW - tumour stage

KW - IBD

KW - CRC

KW - ULCERATIVE-COLITIS

KW - CROHNS COLITIS

KW - POPULATION

KW - METAANALYSIS

KW - NETHERLANDS

KW - GUIDELINES

KW - CARCINOMA

KW - MORTALITY

KW - PROGRAM

KW - COHORT

U2 - 10.1038/sj.bjc.6605359

DO - 10.1038/sj.bjc.6605359

M3 - Article

C2 - 19826420

SN - 0007-0920

VL - 101

SP - 1671

EP - 1675

JO - British Jounal of Cancer

JF - British Jounal of Cancer

IS - 10

ER -

Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease

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