Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials

Fleur Ruijne, Oscar P Kuipers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Natural peptide products are a valuable source of important therapeutic agents, including antibiotics, antivirals and crop protection agents. Aided by an increased understanding of structure-activity relationships of these complex molecules and the biosynthetic machineries that produce them, it has become possible to re-engineer complete machineries and biosynthetic pathways to create novel products with improved pharmacological properties or modified structures to combat antimicrobial resistance. In this review, we will address the progress that has been made using non-ribosomally produced peptides and ribosomally synthesized and post-translationally modified peptides as scaffolds for designed biosynthetic pathways or combinatorial synthesis for the creation of novel peptide antimicrobials.

Original languageEnglish
Article number BST20200425
Pages (from-to)203-215
Number of pages13
JournalBiochemical Society Transactions
Volume49
Issue number1
Early online date13-Jan-2021
DOIs
Publication statusPublished - Apr-2021

Keywords

  • antimicrobials
  • bacteria
  • chemical biology
  • NRPS
  • RiPPS
  • synthetic biology

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