Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma

L E van der Meeren; Lydia Visser; A Diepstra; M Nijland; A van den Berg; P M Kluin

doi:10.1111/his.13445

Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma

L E van der Meeren, Lydia Visser, A Diepstra, M Nijland, A van den Berg, P M Kluin

Translational Immunology Groningen (TRIGR)

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	886-888
Number of pages	3
Journal	Histopathology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/his.13445
Publication status	Published - Apr-2018

Keywords

diffuse large B cell lymphoma
human leucocyte antigen
immune system
immunohistochemistry
FOXP1

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10.1111/his.13445Licence: CC BY-NC-ND

Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large B cell lymphomaFinal publisher's version, 168 KBLicence: CC BY-NC-ND

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@article{a99823b80e694ed7a4bdae7ff2717494,

title = "Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma",

abstract = "As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.",

keywords = "diffuse large B cell lymphoma, human leucocyte antigen, immune system, immunohistochemistry, FOXP1",

author = "{van der Meeren}, {L E} and Lydia Visser and A Diepstra and M Nijland and {van den Berg}, A and Kluin, {P M}",

year = "2018",

month = apr,

doi = "10.1111/his.13445",

language = "English",

volume = "72",

pages = "886--888",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma

AU - van der Meeren, L E

AU - Visser, Lydia

AU - Diepstra, A

AU - Nijland, M

AU - van den Berg, A

AU - Kluin, P M

PY - 2018/4

Y1 - 2018/4

N2 - As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.

AB - As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.

KW - diffuse large B cell lymphoma

KW - human leucocyte antigen

KW - immune system

KW - immunohistochemistry

KW - FOXP1

U2 - 10.1111/his.13445

DO - 10.1111/his.13445

M3 - Comment/Letter to the editor

C2 - 29194719

SN - 0309-0167

VL - 72

SP - 886

EP - 888

JO - Histopathology

JF - Histopathology

IS - 5

ER -

Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma

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