Combined loss of HLA I and HLA II expression is more common in the non-GCB type of diffuse large B cell lymphoma

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Abstract

As an immune escape mechanism tumor cells may downregulate expression of Human Leukocyte Antigens (HLA). Loss of HLA class I and class II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. 1,2 We analyzed HLA class I and class II expression in DLBCL not otherwise specified (NOS) to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FOXP1 expression in non-GCB DLBCL. 3 This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)886-888
Number of pages3
JournalHistopathology
Volume72
Issue number5
DOIs
Publication statusPublished - Apr-2018

Keywords

  • diffuse large B cell lymphoma
  • human leucocyte antigen
  • immune system
  • immunohistochemistry
  • FOXP1

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