Combining designer cells and click chemistry for a one-pot four-step preparation of enantiopure beta-hydroxytriazoles

Wiktor Szymanski, Christiaan Postema, C. Tarabiono, Florian Berthiol, Lachlan Campbell-Verduyn, S. de Wildeman, J.G. de Vries, B.L. Feringa, D.B. Janssen

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)
80 Downloads (Pure)

Abstract

The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of beta-hydroxytriazoles with high enantiomeric excess.
Original languageEnglish
Pages (from-to)2111-2115
Number of pages5
JournalAdvanced Synthesis & Catalysis
Volume352
Issue number13
DOIs
Publication statusPublished - 10-Sept-2010

Keywords

  • reaction cascade
  • halohydrin dehalogenase
  • designer cells
  • click chemistry
  • biocatalysis
  • azides

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