Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses

Gerwin D Rodenburg; Elske J M van Gils; Reinier H Veenhoven; Nienke Jones; Irina Tcherniaeva; Eelko Hak; Loek van Alphen; Guy A M Berbers; Elisabeth A M Sanders

doi:10.1016/j.vaccine.2009.10.151

Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses

Gerwin D Rodenburg, Elske J M van Gils, Reinier H Veenhoven, Nienke Jones, Irina Tcherniaeva, Eelko Hak, Loek van Alphen, Guy A M Berbers, Elisabeth A M Sanders

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In this cohort study we compared IgG antibody levels between infants immunized with 7-valent CRM197-conjugated pneumococcal vaccine (PCV-7) at 2,4 and 11 months and at 2, 3, 4 and 11 months of age,as measured by double adsorption ELISA. Pre- and post-booster levels following the 2 + 1 - and 3 + 1-dose schedule were comparable for 5 out of 7 serotypes except for serotypes 6B and 19F. The proportion of children reaching post-booster antibody thresholds were comparable except for 6B (>= 1.0 mu g/ml and >= 5.0 mu g/ml) and 19F (>= 5.0 mu g/ml). Surveillance studies are warranted for vaccine impact on 6B and 19F disease cases after reduced-dose PCV-7 schedules. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1391-1396
Number of pages	6
Journal	Vaccine
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.vaccine.2009.10.151
Publication status	Published - 3-Feb-2010

Keywords

Pneumococcal conjugate vaccine
Immunogenicity
Reduced-dose schedules
STREPTOCOCCUS-PNEUMONIAE
NASOPHARYNGEAL CARRIAGE
LONGITUDINAL HOUSEHOLD
OTITIS-MEDIA
IMMUNOGENICITY
CHILDREN
DISEASE
SAFETY
IMMUNIZATION
PROTECTION

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Rodenburg, Gerwin D ; van Gils, Elske J M ; Veenhoven, Reinier H ; Jones, Nienke ; Tcherniaeva, Irina ; Hak, Eelko ; van Alphen, Loek ; Berbers, Guy A M ; Sanders, Elisabeth A M. / Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses. In: Vaccine. 2010 ; Vol. 28, No. 5. pp. 1391-1396.

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abstract = "In this cohort study we compared IgG antibody levels between infants immunized with 7-valent CRM197-conjugated pneumococcal vaccine (PCV-7) at 2,4 and 11 months and at 2, 3, 4 and 11 months of age,as measured by double adsorption ELISA. Pre- and post-booster levels following the 2 + 1 - and 3 + 1-dose schedule were comparable for 5 out of 7 serotypes except for serotypes 6B and 19F. The proportion of children reaching post-booster antibody thresholds were comparable except for 6B (>= 1.0 mu g/ml and >= 5.0 mu g/ml) and 19F (>= 5.0 mu g/ml). Surveillance studies are warranted for vaccine impact on 6B and 19F disease cases after reduced-dose PCV-7 schedules. (C) 2009 Elsevier Ltd. All rights reserved.",

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Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses. / Rodenburg, Gerwin D; van Gils, Elske J M; Veenhoven, Reinier H; Jones, Nienke; Tcherniaeva, Irina; Hak, Eelko; van Alphen, Loek; Berbers, Guy A M; Sanders, Elisabeth A M.

In: Vaccine, Vol. 28, No. 5, 03.02.2010, p. 1391-1396.

Research output: Contribution to journal › Article › Academic › peer-review

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