Abstract
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 52-59 |
| Number of pages | 8 |
| Journal | Cardiovascular therapy and prevention |
| Volume | 6 |
| Issue number | 8 |
| Publication status | Published - 2007 |
Keywords
- stem cells
- antithrombotic therapy
- acute myocardial infarction
- BONE-MARROW-CELLS
- PROGENITOR CELLS
- TOPCARE-AMI
- REGENERATION ENHANCEMENT
- TRANSPLANTATION
- TRIAL
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In: Cardiovascular therapy and prevention, Vol. 6, No. 8, 2007, p. 52-59.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Comparative analysis of intramyocardial autotransplantation of postnatal stem cells from peripheral blood and adipose tissue in patients with acute phase of myocardial infarction, ST segment elevation, after effective thrombolytic reperfusion and coronary artery stenting
AU - Kharlamov, A. N.
AU - Smolenskaya, O. G.
AU - Gabinsky, Ya. L.
AU - Bos, E. K.
PY - 2007
Y1 - 2007
N2 - Aim. To compare various techniques of peripheral blood and adipose tissue stem cell (SC) transplantation and identify its optimal method for acute phase of myocardial infarction (MI).Material and methods. The study included 90 patients with acute MI. The participants were randomized into three groups: main group (n=31), comparison group (n=27), and control group (n=32). Main group received five-day combined cytokine therapy, starting 24 hours after randomization; at Day 6-9 after randomization, SC transplantation was performed by artery catheterization. Comparison group received adipose tissue mesenchymal SC. Control group was administered standard therapy only. All assessed parameters were measured before transplantation, and 1, 3, 6, and 12 months after randomization.Results. In comparison group, myocardial contractility increased more rapidly in the short term, but not in the long-term follow-up. Global myocardial contractility increased by 25,2% (pConclusion. Peripheral blood and adipose tissue SC autotransplantation was a highly effective and safe method for acute MI treatment.
AB - Aim. To compare various techniques of peripheral blood and adipose tissue stem cell (SC) transplantation and identify its optimal method for acute phase of myocardial infarction (MI).Material and methods. The study included 90 patients with acute MI. The participants were randomized into three groups: main group (n=31), comparison group (n=27), and control group (n=32). Main group received five-day combined cytokine therapy, starting 24 hours after randomization; at Day 6-9 after randomization, SC transplantation was performed by artery catheterization. Comparison group received adipose tissue mesenchymal SC. Control group was administered standard therapy only. All assessed parameters were measured before transplantation, and 1, 3, 6, and 12 months after randomization.Results. In comparison group, myocardial contractility increased more rapidly in the short term, but not in the long-term follow-up. Global myocardial contractility increased by 25,2% (pConclusion. Peripheral blood and adipose tissue SC autotransplantation was a highly effective and safe method for acute MI treatment.
KW - stem cells
KW - antithrombotic therapy
KW - acute myocardial infarction
KW - BONE-MARROW-CELLS
KW - PROGENITOR CELLS
KW - TOPCARE-AMI
KW - REGENERATION ENHANCEMENT
KW - TRANSPLANTATION
KW - TRIAL
M3 - Article
SN - 1728-8800
VL - 6
SP - 52
EP - 59
JO - Cardiovascular therapy and prevention
JF - Cardiovascular therapy and prevention
IS - 8
ER -