Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes

Christof von Eiff; Alexander W. Friedrich; Karsten Becker; Georg Peters

doi:10.1128/AAC.49.10.4372-4374.2005

Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes

Christof von Eiff, Alexander W. Friedrich, Karsten Becker, Georg Peters

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.

Original language	English
Pages (from-to)	4372-4374
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	10
DOIs	https://doi.org/10.1128/AAC.49.10.4372-4374.2005
Publication status	Published - Oct-2005

Keywords

Acetamides
Anti-Bacterial Agents
Aza Compounds
Cefuroxime
Cephalosporins
Genetic Variation
Microbial Sensitivity Tests
Oxazolidinones
Phenotype
Quinolines
Staphylococcal Infections
Staphylococcus

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title = "Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes",

abstract = "The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.",

keywords = "Acetamides, Anti-Bacterial Agents, Aza Compounds, Cefuroxime, Cephalosporins, Genetic Variation, Microbial Sensitivity Tests, Oxazolidinones, Phenotype, Quinolines, Staphylococcal Infections, Staphylococcus",

author = "{von Eiff}, Christof and Friedrich, {Alexander W.} and Karsten Becker and Georg Peters",

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AU - von Eiff, Christof

AU - Friedrich, Alexander W.

AU - Becker, Karsten

AU - Peters, Georg

PY - 2005/10

Y1 - 2005/10

N2 - The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.

AB - The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.

KW - Acetamides

KW - Anti-Bacterial Agents

KW - Aza Compounds

KW - Cefuroxime

KW - Cephalosporins

KW - Genetic Variation

KW - Microbial Sensitivity Tests

KW - Oxazolidinones

KW - Phenotype

KW - Quinolines

KW - Staphylococcal Infections

KW - Staphylococcus

U2 - 10.1128/AAC.49.10.4372-4374.2005

DO - 10.1128/AAC.49.10.4372-4374.2005

M3 - Article

C2 - 16189125

SN - 0066-4804

VL - 49

SP - 4372

EP - 4374

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

ER -

Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes

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Keywords

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