Abstract
Aim: To compare effectiveness of angiotensin-converting enzyme inhibitors (ACEis)/angiotensin receptor blockers (ARBs) for protecting Type 2 diabetes mellitus (DM2) patients from renal function decline in a real-world setting. Methods: Retrospective cohort study of new ACEi/ARB users in 2007-2012 in an unselected primary care DM2 population. Outcome is decline in renal function stage (combining estimated glomerular filtration rate and albuminuria). Patients were matched on a propensity score. Extended Cox models with time-varying covariates were used to estimate hazard ratios of outcome. Results: The time to renal function decline for ARB users was slightly, but not significantly longer than for ACEi users (hazard ratio: 0.80; 95% CI: 0.58-1.10; p = 0.166). Conclusion: This study did not show significant differences between the classes in preventing renal function decline in DM2 patients in primary care.
Original language | English |
---|---|
Pages (from-to) | 229-237 |
Number of pages | 9 |
Journal | Journal of Comparative Effectiveness Research |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - May-2016 |
Keywords
- angiotensin-converting enzyme inhibitors
- angiotensin receptor blockers
- cohort study
- comparative effectiveness research
- observational research
- primary care
- renal function decline
- Type 2 diabetes
- ALL-CAUSE MORTALITY
- CLINICAL-TRIALS
- KIDNEY-DISEASE
- OLDER-ADULTS
- NEPHROPATHY
- RISK
- SYSTEM
- HYPERTENSION
- METAANALYSIS
- ALBUMINURIA
Datasets
-
GIANTT Groningen Initiative to ANalyse Type 2 diabetes Treatment
Denig, P. (Creator), Universitair Medisch Centrum Groningen / Rijksuniversiteit Groningen, 1-Jan-2007
http://www.giantt.nl and one more link, http://www.giantt.nl/enoutline.htm (show fewer)
Dataset