Comparing the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on renal function decline in diabetes

Yunyu Huang*, Flora M. Haaijer-Ruskamp, Jaco Voorham

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    Aim: To compare effectiveness of angiotensin-converting enzyme inhibitors (ACEis)/angiotensin receptor blockers (ARBs) for protecting Type 2 diabetes mellitus (DM2) patients from renal function decline in a real-world setting. Methods: Retrospective cohort study of new ACEi/ARB users in 2007-2012 in an unselected primary care DM2 population. Outcome is decline in renal function stage (combining estimated glomerular filtration rate and albuminuria). Patients were matched on a propensity score. Extended Cox models with time-varying covariates were used to estimate hazard ratios of outcome. Results: The time to renal function decline for ARB users was slightly, but not significantly longer than for ACEi users (hazard ratio: 0.80; 95% CI: 0.58-1.10; p = 0.166). Conclusion: This study did not show significant differences between the classes in preventing renal function decline in DM2 patients in primary care.

    Original languageEnglish
    Pages (from-to)229-237
    Number of pages9
    JournalJournal of Comparative Effectiveness Research
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - May-2016

    Keywords

    • angiotensin-converting enzyme inhibitors
    • angiotensin receptor blockers
    • cohort study
    • comparative effectiveness research
    • observational research
    • primary care
    • renal function decline
    • Type 2 diabetes
    • ALL-CAUSE MORTALITY
    • CLINICAL-TRIALS
    • KIDNEY-DISEASE
    • OLDER-ADULTS
    • NEPHROPATHY
    • RISK
    • SYSTEM
    • HYPERTENSION
    • METAANALYSIS
    • ALBUMINURIA

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