Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Benedikt Ditz, Jeunard G Boekhoudt, Hananeh Aliee, Fabian J Theis, Martijn Nawijn, Corry-Anke Brandsma, Pieter S Hiemstra, Wim Timens, Gaik W Tew, Michele A Grimbaldeston, Margaret Neighbors, Victor Guryev, Maarten van den Berge, Alen Faiz

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Abstract

More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

Original languageEnglish
Article number00104-2021
Number of pages4
JournalERJ Open Research
Volume7
Issue number2
DOIs
Publication statusE-pub ahead of print - 21-Jun-2021

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