Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Benedikt Ditz; Jeunard G Boekhoudt; Hananeh Aliee; Fabian J Theis; Martijn Nawijn; Corry-Anke Brandsma; Pieter S Hiemstra; Wim Timens; Gaik W Tew; Michele A Grimbaldeston; Margaret Neighbors; Victor Guryev; Maarten van den Berge; Alen Faiz

doi:10.1183/23120541.00104-2021

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Benedikt Ditz, Jeunard G Boekhoudt, Hananeh Aliee, Fabian J Theis, Martijn Nawijn, Corry-Anke Brandsma, Pieter S Hiemstra, Wim Timens, Gaik W Tew, Michele A Grimbaldeston, Margaret Neighbors, Victor Guryev, Maarten van den Berge, Alen Faiz

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

Original language	English
Article number	00104-2021
Number of pages	4
Journal	ERJ Open Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1183/23120541.00104-2021
Publication status	E-pub ahead of print - 21-Jun-2021

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Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment- does it provide new insights?Final publisher's version, 656 KBLicence: CC BY-NC

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Ditz, B., Boekhoudt, J. G., Aliee, H., Theis, F. J., Nawijn, M., Brandsma, C-A., Hiemstra, P. S., Timens, W., Tew, G. W., Grimbaldeston, M. A., Neighbors, M., Guryev, V., van den Berge, M., & Faiz, A. (2021). Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights? ERJ Open Research, 7(2), [00104-2021]. https://doi.org/10.1183/23120541.00104-2021

Ditz, Benedikt ; Boekhoudt, Jeunard G ; Aliee, Hananeh ; Theis, Fabian J ; Nawijn, Martijn ; Brandsma, Corry-Anke ; Hiemstra, Pieter S ; Timens, Wim ; Tew, Gaik W ; Grimbaldeston, Michele A ; Neighbors, Margaret ; Guryev, Victor ; van den Berge, Maarten ; Faiz, Alen. / Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment : does it provide new insights?. In: ERJ Open Research. 2021 ; Vol. 7, No. 2.

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title = "Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?",

abstract = "More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.",

author = "Benedikt Ditz and Boekhoudt, {Jeunard G} and Hananeh Aliee and Theis, {Fabian J} and Martijn Nawijn and Corry-Anke Brandsma and Hiemstra, {Pieter S} and Wim Timens and Tew, {Gaik W} and Grimbaldeston, {Michele A} and Margaret Neighbors and Victor Guryev and {van den Berge}, Maarten and Alen Faiz",

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year = "2021",

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doi = "10.1183/23120541.00104-2021",

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Ditz, B, Boekhoudt, JG, Aliee, H, Theis, FJ, Nawijn, M , Brandsma, C-A, Hiemstra, PS, Timens, W, Tew, GW, Grimbaldeston, MA, Neighbors, M, Guryev, V , van den Berge, M & Faiz, A 2021, 'Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?', ERJ Open Research, vol. 7, no. 2, 00104-2021. https://doi.org/10.1183/23120541.00104-2021

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment : does it provide new insights? / Ditz, Benedikt; Boekhoudt, Jeunard G; Aliee, Hananeh; Theis, Fabian J; Nawijn, Martijn ; Brandsma, Corry-Anke; Hiemstra, Pieter S; Timens, Wim; Tew, Gaik W; Grimbaldeston, Michele A; Neighbors, Margaret; Guryev, Victor ; van den Berge, Maarten; Faiz, Alen.

In: ERJ Open Research, Vol. 7, No. 2, 00104-2021, 21.06.2021.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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AU - Boekhoudt, Jeunard G

AU - Aliee, Hananeh

AU - Theis, Fabian J

AU - Nawijn, Martijn

AU - Brandsma, Corry-Anke

AU - Hiemstra, Pieter S

AU - Timens, Wim

AU - Tew, Gaik W

AU - Grimbaldeston, Michele A

AU - Neighbors, Margaret

AU - Guryev, Victor

AU - van den Berge, Maarten

AU - Faiz, Alen

PY - 2021/6/21

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N2 - More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

AB - More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

U2 - 10.1183/23120541.00104-2021

DO - 10.1183/23120541.00104-2021

M3 - Comment/Letter to the editor

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Ditz B, Boekhoudt JG, Aliee H, Theis FJ, Nawijn M , Brandsma C-A et al. Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights? ERJ Open Research. 2021 Jun 21;7(2). 00104-2021. https://doi.org/10.1183/23120541.00104-2021