Comparison of Human Primary with Human iPS Cell-Derived Dopaminergic Neuron Grafts in the Rat Model for Parkinson's Disease

Su-ping Peng, Sjef Copray*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
214 Downloads (Pure)

Abstract

Neuronal degeneration within the substantia nigra and the loss of the dopaminergic nigro-striatal pathway are the major hallmarks of Parkinson's disease (PD). Grafts of foetal ventral mesencephalic (VM) dopaminergic (DA) neurons into the striatum have been shown to be able to restore striatal dopamine levels and to improve overall PD symptoms. However, human foetus-derived cell grafts are not feasible for clinical application. Autologous induced pluripotent stem cell (iPS cell)-derived DA neurons are emerging as an unprecedented alternative. In this review, we summarize and compare the efficacy of human iPS cell-derived DA neuron grafts to restore normal behaviour in a rat model for PD with that of human foetal primary DA neurons. The differences we observed in the efficacy to restore normal function between the 2 types of DA neuron grafts could be ascribed to intrinsic properties of the iPS cell-derived DA neurons that critically affected survival and proper neurite extension in the striatum after implantation.

Original languageEnglish
Pages (from-to)105-120
Number of pages16
JournalStem cell reviews and reports
Volume12
Issue number1
DOIs
Publication statusPublished - Feb-2016

Keywords

  • iPS cells
  • Ventral mesencephalic dopaminergic neurons
  • Foetal tissue
  • Neurite extension and Parkinson's disease
  • EMBRYONIC STEM-CELLS
  • FETAL MESENCEPHALIC TISSUE
  • SUBSTANTIA-NIGRA
  • HUMAN ES
  • NIGROSTRIATAL PATHWAY
  • DENERVATED STRIATUM
  • NONHUMAN PRIMATE
  • DIFFERENTIATION EFFICIENCY
  • VENTRAL MESENCEPHALON
  • REPROGRAMMING FACTORS

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