Abstract
Background: The instantaneous wave-free ratio (iFR) is a new adenosine-independent index of coronary stenosis severity. Most published data have been based on off-line analyses of pressure recordings in a core laboratory. We prospectively compared real-time iFR and fractional flow reserve (FFR) measurements.
Methods and results: iFR and FFR were measured in 151 coronary stenoses in 108 patients. Repeated iFR measurements were technically simple, showed excellent agreement [r(s)=0.99; p
Conclusions: Real-time iFR measurements are easily performed, have excellent diagnostic performance and confirm available off-line core laboratory data. The excellent agreement between repeated iFR measurements demonstrates the reliability of single measurements. Combining iFR with FFR in a hybrid strategy enhances diagnostic accuracy, exposing fewer patients to adenosine. Overall, iFR is a promising method, but still requires prospective clinical endpoint trial evaluation. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | International Journal of Cardiology |
| Volume | 199 |
| DOIs | |
| Publication status | Published - 15-Nov-2015 |
Keywords
- Instantaneous wave-free ratio
- Real-time
- Physiological assessment
- Coronary stenosis
- Intermediate stenosis
- Hydrostatic pressure
- PERCUTANEOUS CORONARY INTERVENTION
- ADENOSINE-INDEPENDENT INDEX
- STENOSIS SEVERITY
- MULTIVESSEL EVALUATION
- FUNCTIONAL SEVERITY
- INTENSITY ANALYSIS
- ARTERY STENOSES
- BLOOD-FLOW
- FOLLOW-UP
- ANGIOGRAPHY