Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation

MR van Eerde, HH Kampinga*, BG Szabo, Z Vujaskovic

*Corresponding author for this work

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    Abstract

    The purpose of this study is to define differences in radiation sensitivity among rat strains using breathing frequency and lung perfusion as end points of radiation-induced lung injury. The results have confirmed previous findings in mice showing that-under stringently controlled iso-dose/volume irradiation conditions, substantial differences can be found in susceptibility to functional lungs damage after radiation. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)313-316
    Number of pages4
    JournalRadiotherapy and Oncology
    Volume58
    Issue number3
    Publication statusPublished - Mar-2001

    Keywords

    • radiation
    • lung
    • rat strains
    • INDUCED PULMONARY FIBROSIS
    • BREAST-CANCER
    • MOUSE LUNG
    • DEPENDENT DIFFERENCES
    • RADIOTHERAPY
    • PNEUMONITIS
    • RADIOSENSITIVITY
    • SUSCEPTIBILITY
    • SENSITIVITY
    • INHERITANCE

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