Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial

Constanze Scholman; Jeroen M Westra; Manon A Zwakenberg; Jan Wedman; Bert van der Vegt; Roel J H M Steenbakkers; Sjoukje F Oosting; Gyorgy B Halmos; Bernard F A M van der Laan; Boudewijn E C Plaat

doi:10.1111/coa.14293

Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial

Constanze Scholman^*, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).

DESIGN: Prospective randomised controlled trial.

SETTING: Tertiary head and neck oncologic center.

PARTICIPANTS: 257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.

MAIN OUTCOME MEASURES: Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.

RESULTS: Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).

CONCLUSIONS: Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.

TRIAL REGISTRATION: This randomised clinical trial was registered at the research register UMCG with the number 201500918.

Original language	English
Journal	Clinical Otolaryngology
DOIs	https://doi.org/10.1111/coa.14293
Publication status	E-pub ahead of print - 14-Feb-2025

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Scholman, C., Westra, J. M., Zwakenberg, M. A., Wedman, J., van der Vegt, B., Steenbakkers, R. J. H. M., Oosting, S. F., Halmos, G. B., van der Laan, B. F. A. M., & Plaat, B. E. C. (2025). Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial. Clinical Otolaryngology. Advance online publication. https://doi.org/10.1111/coa.14293

@article{5de9e55fd9f1411db8c638cbc13232ef,

title = "Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial",

abstract = "OBJECTIVES: Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).DESIGN: Prospective randomised controlled trial.SETTING: Tertiary head and neck oncologic center.PARTICIPANTS: 257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.MAIN OUTCOME MEASURES: Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.RESULTS: Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).CONCLUSIONS: Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.TRIAL REGISTRATION: This randomised clinical trial was registered at the research register UMCG with the number 201500918.",

author = "Constanze Scholman and Westra, {Jeroen M} and Zwakenberg, {Manon A} and Jan Wedman and {van der Vegt}, Bert and Steenbakkers, {Roel J H M} and Oosting, {Sjoukje F} and Halmos, {Gyorgy B} and {van der Laan}, {Bernard F A M} and Plaat, {Boudewijn E C}",

note = "{\textcopyright} 2025 The Author(s). Clinical Otolaryngology published by John Wiley & Sons Ltd.",

year = "2025",

month = feb,

day = "14",

doi = "10.1111/coa.14293",

language = "English",

journal = "Clinical Otolaryngology",

issn = "0307-7772",

publisher = "Wiley",

}

Scholman, C , Westra, JM, Zwakenberg, MA, Wedman, J , van der Vegt, B , Steenbakkers, RJHM , Oosting, SF , Halmos, GB, van der Laan, BFAM & Plaat, BEC 2025, 'Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial', Clinical Otolaryngology. https://doi.org/10.1111/coa.14293

Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial. / Scholman, Constanze ; Westra, Jeroen M; Zwakenberg, Manon A et al.
In: Clinical Otolaryngology, 14.02.2025.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer

T2 - A Randomised Controlled Trial

AU - Scholman, Constanze

AU - Westra, Jeroen M

AU - Zwakenberg, Manon A

AU - Wedman, Jan

AU - van der Vegt, Bert

AU - Steenbakkers, Roel J H M

AU - Oosting, Sjoukje F

AU - Halmos, Gyorgy B

AU - van der Laan, Bernard F A M

AU - Plaat, Boudewijn E C

PY - 2025/2/14

Y1 - 2025/2/14

N2 - OBJECTIVES: Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).DESIGN: Prospective randomised controlled trial.SETTING: Tertiary head and neck oncologic center.PARTICIPANTS: 257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.MAIN OUTCOME MEASURES: Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.RESULTS: Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).CONCLUSIONS: Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.TRIAL REGISTRATION: This randomised clinical trial was registered at the research register UMCG with the number 201500918.

AB - OBJECTIVES: Early detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).DESIGN: Prospective randomised controlled trial.SETTING: Tertiary head and neck oncologic center.PARTICIPANTS: 257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.MAIN OUTCOME MEASURES: Local recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.RESULTS: Detection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).CONCLUSIONS: Local recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.TRIAL REGISTRATION: This randomised clinical trial was registered at the research register UMCG with the number 201500918.

U2 - 10.1111/coa.14293

DO - 10.1111/coa.14293

M3 - Article

C2 - 39952630

SN - 0307-7772

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

ER -

Scholman C , Westra JM, Zwakenberg MA, Wedman J , van der Vegt B , Steenbakkers RJHM et al. Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial. Clinical Otolaryngology. 2025 Feb 14. Epub 2025 Feb 14. doi: 10.1111/coa.14293