COMPLEMENT ACTIVATION AND THE PRODUCTION OF INFLAMMATORY MEDIATORS DURING THE TREATMENT OF SEVERE SEPSIS IN HUMANS

ASM DOFFERHOFF; HJ DEJONG; VJJ BOM; J VANDERMEER; PC LIMBURG; HG DEVRIESHOSPERS; J MARRINK; POM MULDER; J WEITS

COMPLEMENT ACTIVATION AND THE PRODUCTION OF INFLAMMATORY MEDIATORS DURING THE TREATMENT OF SEVERE SEPSIS IN HUMANS

ASM DOFFERHOFF, HJ DEJONG, VJJ BOM, J VANDERMEER, PC LIMBURG, HG DEVRIESHOSPERS, J MARRINK, POM MULDER, J WEITS

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Abstract

Sepsis or septic shock is frequently associated with activation of the complement system, coagulation and fibrinolytic changes and the release of several cytokines. In this study we analyzed the relation of complement activation to the inflammatory mediators, hemodynamic and biochemical parameters and severity of illness and outcome in 20 consecutive patients with clinically defined sepsis. Levels of C3a and C3d were elevated in 90% of the patients (median levels 0.19 mg/l and 8.6 mg/l respectively) in comparison to 14% and 42%, respectively of 7 patients with non-septic shock. Levels of C4 were decreased in only 1 of the 20 septic patients. Levels of TNF and IL-6 were elevated in 94% and 100% of the patients, respectively (median levels 122 ng/l and 1300 U/ml) and were clearly interrelated (r=0.67, p

Original language	English
Pages (from-to)	197-204
Number of pages	8
Journal	Scandinavian journal of infectious diseases
Volume	24
Issue number	2
Publication status	Published - 1992

Keywords

TUMOR-NECROSIS-FACTOR
RAW 264.7 CELLS
LIPOPROTEIN-LIPASE
HUMAN-MONOCYTES
TISSUE-INJURY
PLASMA-LEVELS
ENDOTOXIN
CACHECTIN
INTERLEUKIN-6
LIPOPOLYSACCHARIDE

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title = "COMPLEMENT ACTIVATION AND THE PRODUCTION OF INFLAMMATORY MEDIATORS DURING THE TREATMENT OF SEVERE SEPSIS IN HUMANS",

abstract = "Sepsis or septic shock is frequently associated with activation of the complement system, coagulation and fibrinolytic changes and the release of several cytokines. In this study we analyzed the relation of complement activation to the inflammatory mediators, hemodynamic and biochemical parameters and severity of illness and outcome in 20 consecutive patients with clinically defined sepsis. Levels of C3a and C3d were elevated in 90% of the patients (median levels 0.19 mg/l and 8.6 mg/l respectively) in comparison to 14% and 42%, respectively of 7 patients with non-septic shock. Levels of C4 were decreased in only 1 of the 20 septic patients. Levels of TNF and IL-6 were elevated in 94% and 100% of the patients, respectively (median levels 122 ng/l and 1300 U/ml) and were clearly interrelated (r=0.67, p",

keywords = "TUMOR-NECROSIS-FACTOR, RAW 264.7 CELLS, LIPOPROTEIN-LIPASE, HUMAN-MONOCYTES, TISSUE-INJURY, PLASMA-LEVELS, ENDOTOXIN, CACHECTIN, INTERLEUKIN-6, LIPOPOLYSACCHARIDE",

author = "ASM DOFFERHOFF and HJ DEJONG and VJJ BOM and J VANDERMEER and PC LIMBURG and HG DEVRIESHOSPERS and J MARRINK and POM MULDER and J WEITS",

year = "1992",

language = "English",

volume = "24",

pages = "197--204",

journal = "Scandinavian journal of infectious diseases",

issn = "0036-5548",

number = "2",

}

TY - JOUR

T1 - COMPLEMENT ACTIVATION AND THE PRODUCTION OF INFLAMMATORY MEDIATORS DURING THE TREATMENT OF SEVERE SEPSIS IN HUMANS

AU - DOFFERHOFF, ASM

AU - DEJONG, HJ

AU - BOM, VJJ

AU - VANDERMEER, J

AU - LIMBURG, PC

AU - DEVRIESHOSPERS, HG

AU - MARRINK, J

AU - MULDER, POM

AU - WEITS, J

PY - 1992

Y1 - 1992

N2 - Sepsis or septic shock is frequently associated with activation of the complement system, coagulation and fibrinolytic changes and the release of several cytokines. In this study we analyzed the relation of complement activation to the inflammatory mediators, hemodynamic and biochemical parameters and severity of illness and outcome in 20 consecutive patients with clinically defined sepsis. Levels of C3a and C3d were elevated in 90% of the patients (median levels 0.19 mg/l and 8.6 mg/l respectively) in comparison to 14% and 42%, respectively of 7 patients with non-septic shock. Levels of C4 were decreased in only 1 of the 20 septic patients. Levels of TNF and IL-6 were elevated in 94% and 100% of the patients, respectively (median levels 122 ng/l and 1300 U/ml) and were clearly interrelated (r=0.67, p

AB - Sepsis or septic shock is frequently associated with activation of the complement system, coagulation and fibrinolytic changes and the release of several cytokines. In this study we analyzed the relation of complement activation to the inflammatory mediators, hemodynamic and biochemical parameters and severity of illness and outcome in 20 consecutive patients with clinically defined sepsis. Levels of C3a and C3d were elevated in 90% of the patients (median levels 0.19 mg/l and 8.6 mg/l respectively) in comparison to 14% and 42%, respectively of 7 patients with non-septic shock. Levels of C4 were decreased in only 1 of the 20 septic patients. Levels of TNF and IL-6 were elevated in 94% and 100% of the patients, respectively (median levels 122 ng/l and 1300 U/ml) and were clearly interrelated (r=0.67, p

KW - TUMOR-NECROSIS-FACTOR

KW - RAW 264.7 CELLS

KW - LIPOPROTEIN-LIPASE

KW - HUMAN-MONOCYTES

KW - TISSUE-INJURY

KW - PLASMA-LEVELS

KW - ENDOTOXIN

KW - CACHECTIN

KW - INTERLEUKIN-6

KW - LIPOPOLYSACCHARIDE

M3 - Article

SN - 0036-5548

VL - 24

SP - 197

EP - 204

JO - Scandinavian journal of infectious diseases

JF - Scandinavian journal of infectious diseases

IS - 2

ER -

COMPLEMENT ACTIVATION AND THE PRODUCTION OF INFLAMMATORY MEDIATORS DURING THE TREATMENT OF SEVERE SEPSIS IN HUMANS

Abstract

Keywords

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