Complications related to the management of mycobacterium ulcerans disease in Bénin: A plea for early case detection

Mahoutondji Yves Thierry Barogui

    Research output: ThesisThesis fully internal (DIV)

    1249 Downloads (Pure)


    Buruli ulcer is infectious neglected tropical disease caused by Mycobacterium ulcerans. Usually
    patients report to the hospital at an advanced stage of the disease resulting in prolonged hospital
    admission, eventually, severe functional limitations and heavy and socio-economic burden. The
    mode of transmission is still unknown. Early case detection associated with specific antimicrobial
    treatment is the main strategy to control this disease.
    This thesis aims to study the prevention of Buruli ulcer. It especially focuses on the efficacy of
    community health volunteers in the early case detection, the rational use of nonspecific antibiotics
    for prophylaxis after surgery or in case of suspected secondary infection, the paradoxical reaction
    and the functional limitations after specific antibiotic treatment in patients affected by Buruli
    Our findings will impact the direction of future control activities in Buruli ulcer disease.
    Strengths and limitations of the studies contained in this thesis as well as direction for future
    research are presented. To conclude, it appears that of all strategies currently explored and
    discussed here, an optimized strategy for early case detection has the highest priority since it
    will reduce the
    • duration of treatment,
    • secondary infection,
    • paradoxical reaction,
    • permanent functional limitation,
    • direct and indirect financial burden and,
    • overall suffering caused by this diseases.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • van der Werf, Tjip, Supervisor
    • Stienstra, Ymkje, Co-supervisor
    Award date8-Feb-2016
    Place of Publication[Groningen]
    Print ISBNs978-90-367-8554-9
    Electronic ISBNs978-90-367-8555-6
    Publication statusPublished - 2016

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