Compositions and methods for treating senescence-associated diseases and disorders.

Remi-Martin Laberge (Inventor), Judith Campisi (Inventor), Albert Davalos (Inventor), Jose Alberto Lopez-Dominguez (Inventor), Marco Demaria (Inventor), Nathaniel David (Inventor), Alain Philippe Vasserot (Inventor), Darren J. Baker (Inventor), Bennett G. Childs (Inventor), James L. Kirkland (Inventor), Tamar Tchkonia (Inventor), Jan M. A. van Deursen (Inventor), Yi Zhu (Inventor)

Research output: Patent


Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.
Original languageEnglish
Patent numberWO2017008060
Priority date08/07/2015
Publication statusPublished - 12-Jan-2017

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