Compositions and methods for treating senescence-associated diseases and disorders.

Remi-Martin Laberge; Judith Campisi; Albert Davalos; Jose Alberto Lopez-Dominguez; Marco Demaria; Nathaniel David; Alain Philippe Vasserot; Darren J. Baker; Bennett G. Childs; James L. Kirkland; Tamar Tchkonia; Jan M. A. van Deursen; Yi Zhu

Compositions and methods for treating senescence-associated diseases and disorders.

Remi-Martin Laberge (Inventor), Judith Campisi (Inventor), Albert Davalos (Inventor), Jose Alberto Lopez-Dominguez (Inventor), Marco Demaria (Inventor), Nathaniel David (Inventor), Alain Philippe Vasserot (Inventor), Darren J. Baker (Inventor), Bennett G. Childs (Inventor), James L. Kirkland (Inventor), Tamar Tchkonia (Inventor), Jan M. A. van Deursen (Inventor), Yi Zhu (Inventor)

Research output: Patent

Abstract

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.

Original language	English
Patent number	WO2017008060
Priority date	08/07/2015
Publication status	Published - 12-Jan-2017

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https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017008060A1&KC=A1&FT=D&ND=3&date=20170112&DB=&locale=en_EP

Cite this

Laberge, R-M., Campisi, J., Davalos, A., Lopez-Dominguez , J. A., Demaria, M., David, N., Vasserot, A. P., Baker, D. J., Childs, B. G., Kirkland, J. L., Tchkonia, T., van Deursen, J. M. A., & Zhu, Y. (2017). Compositions and methods for treating senescence-associated diseases and disorders. (Patent No. WO2017008060). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017008060A1&KC=A1&FT=D&ND=3&date=20170112&DB=&locale=en_EP

Laberge, Remi-Martin (Inventor) ; Campisi, Judith (Inventor) ; Davalos, Albert (Inventor) ; Lopez-Dominguez , Jose Alberto (Inventor) ; Demaria, Marco (Inventor) ; David, Nathaniel (Inventor) ; Vasserot, Alain Philippe (Inventor) ; Baker, Darren J. (Inventor) ; Childs, Bennett G. (Inventor) ; Kirkland, James L. (Inventor) ; Tchkonia, Tamar (Inventor) ; van Deursen, Jan M. A. (Inventor) ; Zhu, Yi (Inventor). / Compositions and methods for treating senescence-associated diseases and disorders. Patent No.: WO2017008060. Jan 12, 2017.

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title = "Compositions and methods for treating senescence-associated diseases and disorders.",

abstract = "Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.",

author = "Remi-Martin Laberge and Judith Campisi and Albert Davalos and Lopez-Dominguez, {Jose Alberto} and Marco Demaria and Nathaniel David and Vasserot, {Alain Philippe} and Baker, {Darren J.} and Childs, {Bennett G.} and Kirkland, {James L.} and Tamar Tchkonia and {van Deursen}, {Jan M. A.} and Yi Zhu",

year = "2017",

month = jan,

day = "12",

language = "English",

type = "Patent",

note = "WO2017008060",

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Laberge, R-M, Campisi, J, Davalos, A, Lopez-Dominguez , JA, Demaria, M, David, N, Vasserot, AP, Baker, DJ, Childs, BG, Kirkland, JL, Tchkonia, T, van Deursen, JMA & Zhu, Y Jan. 12 2017, Compositions and methods for treating senescence-associated diseases and disorders., Patent No. WO2017008060. <https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017008060A1&KC=A1&FT=D&ND=3&date=20170112&DB=&locale=en_EP>

Compositions and methods for treating senescence-associated diseases and disorders. / Laberge, Remi-Martin (Inventor); Campisi, Judith (Inventor); Davalos, Albert (Inventor); Lopez-Dominguez , Jose Alberto (Inventor); Demaria, Marco (Inventor); David, Nathaniel (Inventor); Vasserot, Alain Philippe (Inventor); Baker, Darren J. (Inventor); Childs, Bennett G. (Inventor); Kirkland, James L. (Inventor); Tchkonia, Tamar (Inventor); van Deursen, Jan M. A. (Inventor); Zhu, Yi (Inventor).

Patent No.: WO2017008060. Jan 12, 2017.

Research output: Patent

TY - PAT

T1 - Compositions and methods for treating senescence-associated diseases and disorders.

AU - Laberge, Remi-Martin

AU - Campisi, Judith

AU - Davalos, Albert

AU - Lopez-Dominguez , Jose Alberto

AU - Demaria, Marco

AU - David, Nathaniel

AU - Vasserot, Alain Philippe

AU - Baker, Darren J.

AU - Childs, Bennett G.

AU - Kirkland, James L.

AU - Tchkonia, Tamar

AU - van Deursen, Jan M. A.

AU - Zhu, Yi

PY - 2017/1/12

Y1 - 2017/1/12

N2 - Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.

AB - Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.

M3 - Patent

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ER -