Compound for the prophylaxis or treatment of organ damage

Adrianus Cornelis van der Graaf (Inventor), Robert Henk Henning (Inventor), Leo Edwin Deelman (Inventor), Gerrit Jan Willem Euverink (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney damage. Specifically, the present invention relates to 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially diabetic kidney organ damage.
Original languageEnglish
Patent numberWO2016188766
Priority date22/05/2015
Publication statusPublished - 1-Dec-2016

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