Computational Design of TNF Ligand-Based Protein Therapeutics

Almer M. van der Sloot, Wim J. Quax*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

Members of the TNF ligand and TNF receptor family are controlling a variety of cellular processes including host defence, development, autoimmunity, inflammation, and tumor surveillance. Not surprisingly, both families are considered to be an attractive collection of therapeutic targets. Most therapeutics acting on these targets are protein-based drugs. In this review we will discuss current progress in computational design of protein-based therapeutics acting on TNF ligands or TNF receptors. In addition, we describe how this technology can also be used to design tools to study signaling in the TNF ligand/receptor family.
Original languageEnglish
Title of host publicationADVANCES IN TNF FAMILY RESEARCH
EditorsD Wallach, A Kovalenko, M Feldman
Place of PublicationBERLIN
PublisherSpringer
Pages521-534
Number of pages14
ISBN (Print)978-1-4419-6611-7
DOIs
Publication statusPublished - 2011
Event12th Biennial International TNF Conference - San Lorenzo del Escorial, Spain
Duration: 26-Apr-200929-Apr-2009

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSPRINGER-VERLAG BERLIN
Volume691
ISSN (Print)0065-2598

Conference

Conference12th Biennial International TNF Conference
Country/TerritorySpain
CitySan Lorenzo del Escorial
Period26/04/200929/04/2009

Keywords

  • APOPTOSIS-INDUCING LIGAND
  • RECEPTOR-SELECTIVE MUTANTS
  • BINDING-SPECIFICITY
  • MONOCLONAL-ANTIBODIES
  • RATIONAL DESIGN
  • DECOY RECEPTORS
  • IN-VIVO
  • TRAIL
  • REDESIGN
  • DEATH

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