Abstract
Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kröger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH & Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. © 2012 Frederick Furness Publishing.
| Original language | English |
|---|---|
| Pages (from-to) | 30-33 |
| Number of pages | 4 |
| Journal | ONdrugDelivery |
| Issue number | APRIL |
| Publication status | Published - 1-Apr-2012 |
Keywords
- antibiotic agent
- chlorofluorocarbon
- colistimethate
- propellant
- aerosol
- airflow
- article
- computational fluid dynamics
- cystic fibrosis
- drug industry
- geometry
- heat transfer
- human
- inhalation
- metered dose inhaler
- nebulizer
- powder inhaler
- respiratory system
- spray drying
- tuberculosis