Computational studies of influenza hemagglutinin: How does it mediate membrane fusion?

Sander Boonstra

Research output: ThesisThesis fully internal (DIV)

677 Downloads (Pure)

Abstract

Hemagglutinin (HA) is a viral membrane protein responsible for the initial steps of the entry of influenza virus into the host cell. It mediates binding of the virus particle to the host cell membrane and catalyzes fusion of the viral membrane with that of the host. HA is therefore a major target in the development of antiviral strategies. The fusion of two membranes is thermodynamically favourable, but involves high activation barriers and proceeds through several intermediate states. This thesis focuses on the molecular details of the large conformational changes that take place in HA to catalyze the membrane fusion process. It describes how molecular dynamics simulations are used to determine key amino acid interactions during the HA rearrangements and the free energy that a single HA can deliver.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • van der Giessen, Erik, Supervisor
  • Onck, Patrick, Supervisor
Award date22-Dec-2017
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-0252-9, 978-94-034-0253-6
Publication statusPublished - 2017

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