Computed Tomography Screening for Early Lung Cancer, COPD and Cardiovascular Disease in Shanghai: Rationale and Design of a Population-based Comparative Study

Y Du, Qiong Lin, Grigory Sidorenkov, Marleen Vonder, Jiali Cai, Gertruida H de Bock, Yu Guan, Yi Xia, Xiuxiu Zhou, Di Zhang, Mieneke Rook, Rozemarijn Vliegenthart, Marjolein Heuvelmans, Monique Dorrius, Peter Ooijen, van, Harry J. M. Groen, Pim Harst, van der, Yi Xiao, Zhaoxiang Ye, Xueqian XieWenjing Wang, Matthijs Oudkerk, Fan Li, Shiyuan Liu*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
26 Downloads (Pure)

Abstract

Rationale and Objectives: To describe the rational and design of a population-based comparative study. The objective of the study is to assess the screening performance of volume-based management of CT-detected lung nodule in comparison to diameter-based management, and to improve the effectiveness of CT screening for chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), in addition to lung cancer, based on quantitative measurement of CT imaging biomarkers in a Chinese screening setting.

Materials and Methods: A population-based comparative study is being performed, including 10,000 asymptomatic participants between 40 and 74 years old from Shanghai urban population. Participants in the intervention group undergo a low-dose chest and cardiac CT scan at baseline and 1 year later, and are managed according to NELCIN-B3 protocol. Participants in the control group undergo a low-dose chest CT scan according to the routine CT protocol and are managed according to the clinical practice. Epidemiological data are collected through questionnaires. In the fourth year from baseline, the diagnosis of the three diseases will be collected.

Results: The unnecessary referral rate will be compared between NELCIN-B3 and standard protocol for managing early-detected lung nodules. The effectiveness of quantitative measurement of CT imaging biomarkers for early detection of lung cancer, COPD and CVD will be evaluated.

Conclusion: We expect that the quantitative assessment of the CT imaging biomarkers will reduce the number of unnecessary referrals for early detected lung nodules, and will improve the early detection of COPD and CVD in a Chinese urban population.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalAcademic Radiology
Volume28
Issue number1
Early online date2020
DOIs
Publication statusPublished - Jan-2021

Keywords

  • Lung cancer
  • Chronic obstructive pulmonary disease
  • Cardiovascular disease
  • Biomarkers
  • Screening
  • Computed tomography

Cite this