Computed Tomography Structural Lung Changes in Discordant Airflow Limitation

Firdaus A. A. Mohamed Hoesein; Pim A. de Jong; Jan-Willem J. Lammers; Willem PThM Mali; Michael Schmidt; Harry J. de Koning; Carlijn van der Aalst; Matthijs Oudkerk; Rozemarijn Vliegenthart; Bram van Ginneken; Eva M. van Rikxoort; Pieter Zanen

doi:10.1371/journal.pone.0065177

Computed Tomography Structural Lung Changes in Discordant Airflow Limitation

Firdaus A. A. Mohamed Hoesein^*
, Pim A. de Jong
, Jan-Willem J. Lammers
, Willem PThM Mali
, Michael Schmidt
, Harry J. de Koning
, Carlijn van der Aalst
, Matthijs Oudkerk
, Rozemarijn Vliegenthart
, Bram van Ginneken
, Eva M. van Rikxoort
, Pieter Zanen

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

255 Downloads (Pure)

Abstract

Background: There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVC

Methods: A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15th percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70%; group 2LLN; and group 370% but FEV1

Results: Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15th percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6% versus 85.6% (all p

Conclusion: Subjects with an FEV1/FVC

Original language	English
Article number	e65177
Number of pages	5
Journal	PLoS ONE
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0065177
Publication status	Published - 13-Jun-2013

Keywords

OBSTRUCTIVE PULMONARY-DISEASE
FEV1/FVC LESS-THAN-0.70
DIAGNOSING COPD
EMPHYSEMA
POPULATION
PREVALENCE
RISK
ASSOCIATION
THRESHOLDS
SEVERITY

Access to Document

10.1371/journal.pone.0065177Licence: CC BY

Computed Tomography Structural Lung Changes in Discordant Airflow LimitationFinal publisher's version, 143 KBLicence: CC BY

Handle.net

Persistent link

Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)
Oudkerk, M. (Creator), Groen, H. J. M. (Creator), Van Klaveren, R. J. (Creator), de Koning, H. J. (Creator), Mali, W. P. T. M. (Creator) & Lammers, J.-W. J. (Creator), University of Groningen, 2018
http://www.nelsonproject.nl/infobrochure.html
Dataset

Cite this

@article{7740014cf2a74ba882cdcf44710767c1,

title = "Computed Tomography Structural Lung Changes in Discordant Airflow Limitation",

abstract = "Background: There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVCMethods: A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15th percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70\%; group 2LLN; and group 370\% but FEV1Results: Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15th percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6\% versus 85.6\% (all pConclusion: Subjects with an FEV1/FVC",

keywords = "OBSTRUCTIVE PULMONARY-DISEASE, FEV1/FVC LESS-THAN-0.70, DIAGNOSING COPD, EMPHYSEMA, POPULATION, PREVALENCE, RISK, ASSOCIATION, THRESHOLDS, SEVERITY",

author = "Hoesein, \{Firdaus A. A. Mohamed\} and \{de Jong\}, \{Pim A.\} and Lammers, \{Jan-Willem J.\} and Mali, \{Willem PThM\} and Michael Schmidt and \{de Koning\}, \{Harry J.\} and \{van der Aalst\}, Carlijn and Matthijs Oudkerk and Rozemarijn Vliegenthart and \{van Ginneken\}, Bram and \{van Rikxoort\}, \{Eva M.\} and Pieter Zanen",

year = "2013",

month = jun,

day = "13",

doi = "10.1371/journal.pone.0065177",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "PUBLIC LIBRARY SCIENCE",

number = "6",

}

TY - JOUR

T1 - Computed Tomography Structural Lung Changes in Discordant Airflow Limitation

AU - Hoesein, Firdaus A. A. Mohamed

AU - de Jong, Pim A.

AU - Lammers, Jan-Willem J.

AU - Mali, Willem PThM

AU - Schmidt, Michael

AU - de Koning, Harry J.

AU - van der Aalst, Carlijn

AU - Oudkerk, Matthijs

AU - Vliegenthart, Rozemarijn

AU - van Ginneken, Bram

AU - van Rikxoort, Eva M.

AU - Zanen, Pieter

PY - 2013/6/13

Y1 - 2013/6/13

N2 - Background: There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVCMethods: A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15th percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70%; group 2LLN; and group 370% but FEV1Results: Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15th percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6% versus 85.6% (all pConclusion: Subjects with an FEV1/FVC

AB - Background: There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVCMethods: A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15th percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70%; group 2LLN; and group 370% but FEV1Results: Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15th percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6% versus 85.6% (all pConclusion: Subjects with an FEV1/FVC

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - FEV1/FVC LESS-THAN-0.70

KW - DIAGNOSING COPD

KW - EMPHYSEMA

KW - POPULATION

KW - PREVALENCE

KW - RISK

KW - ASSOCIATION

KW - THRESHOLDS

KW - SEVERITY

U2 - 10.1371/journal.pone.0065177

DO - 10.1371/journal.pone.0065177

M3 - Article

C2 - 23785411

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 6

M1 - e65177

ER -

Computed Tomography Structural Lung Changes in Discordant Airflow Limitation

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Datasets

Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)

Cite this