Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms

K. Michielsen; H. De Raedt; N. García

doi:10.1118/1.597955

Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms

K. Michielsen, H. De Raedt, N. García

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Abstract

A simulation technique is employed to explore the possibility of locating millimeter-sized objects, immersed in turbid media, from time-gated measurements of the transmitted or reflected light. The simulation results for tissuelike phantoms are compared to experimental transillumination data and excellent agreement is found. Simulations of time-gated reflection experiments show that it is possible to detect objects of I mm diameter. This may open new possibilities for medical diagnosis of breast cancer in an early stage. (C) 1997 American Association of Physicists in Medicine.

Original language	English
Pages (from-to)	1688-1695
Number of pages	8
Journal	Medical Physics
Volume	24
Issue number	11
DOIs	https://doi.org/10.1118/1.597955
Publication status	Published - Nov-1997

Keywords

optical transillumination
time-resolved imaging
diffusion equation
breast cancer
PHOTON-DENSITY WAVES
MULTIPLE-SCATTERING MEDIA
FINITE-ELEMENT METHOD
TURBID MEDIA
OF-FLIGHT
ABSORPTION-COEFFICIENTS
STATISTICAL PHYSICS
LIGHT
SPECTROSCOPY
PROPAGATION

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title = "Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms",

abstract = "A simulation technique is employed to explore the possibility of locating millimeter-sized objects, immersed in turbid media, from time-gated measurements of the transmitted or reflected light. The simulation results for tissuelike phantoms are compared to experimental transillumination data and excellent agreement is found. Simulations of time-gated reflection experiments show that it is possible to detect objects of I mm diameter. This may open new possibilities for medical diagnosis of breast cancer in an early stage. (C) 1997 American Association of Physicists in Medicine.",

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author = "K. Michielsen and Raedt, {H. De} and N. Garc{\'i}a",

note = "Relation: http://www.rug.nl/natuurkunde/ date_submitted:2006 Rights: University of Groningen. Materials Science Centre",

year = "1997",

month = nov,

doi = "10.1118/1.597955",

language = "English",

volume = "24",

pages = "1688--1695",

journal = "Medical Physics",

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number = "11",

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T1 - Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms

AU - Michielsen, K.

AU - Raedt, H. De

AU - García, N.

N1 - Relation: http://www.rug.nl/natuurkunde/ date_submitted:2006 Rights: University of Groningen. Materials Science Centre

PY - 1997/11

Y1 - 1997/11

N2 - A simulation technique is employed to explore the possibility of locating millimeter-sized objects, immersed in turbid media, from time-gated measurements of the transmitted or reflected light. The simulation results for tissuelike phantoms are compared to experimental transillumination data and excellent agreement is found. Simulations of time-gated reflection experiments show that it is possible to detect objects of I mm diameter. This may open new possibilities for medical diagnosis of breast cancer in an early stage. (C) 1997 American Association of Physicists in Medicine.

AB - A simulation technique is employed to explore the possibility of locating millimeter-sized objects, immersed in turbid media, from time-gated measurements of the transmitted or reflected light. The simulation results for tissuelike phantoms are compared to experimental transillumination data and excellent agreement is found. Simulations of time-gated reflection experiments show that it is possible to detect objects of I mm diameter. This may open new possibilities for medical diagnosis of breast cancer in an early stage. (C) 1997 American Association of Physicists in Medicine.

KW - optical transillumination

KW - time-resolved imaging

KW - diffusion equation

KW - breast cancer

KW - PHOTON-DENSITY WAVES

KW - MULTIPLE-SCATTERING MEDIA

KW - FINITE-ELEMENT METHOD

KW - TURBID MEDIA

KW - OF-FLIGHT

KW - ABSORPTION-COEFFICIENTS

KW - STATISTICAL PHYSICS

KW - LIGHT

KW - SPECTROSCOPY

KW - PROPAGATION

U2 - 10.1118/1.597955

DO - 10.1118/1.597955

M3 - Article

SN - 0094-2405

VL - 24

SP - 1688

EP - 1695

JO - Medical Physics

JF - Medical Physics

IS - 11

ER -

Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms

Abstract

Keywords

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