COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients

S.A. Ivanova (Svetlana Ivanova); Diana Z. Paderina; Anastasiia S Boiko; O. Fedorenko; Ivan V Pozhidaev; Vladimir Tigunsev; E. G. Kornetova; Nikolay A. Bokhan; Bob Wilffert; Anton Loonen

doi:10.1109/CSGB51356.2020.9214668

COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients

S.A. Ivanova (Svetlana Ivanova), Diana Z. Paderina, Anastasiia S Boiko, O. Fedorenko, Ivan V Pozhidaev, Vladimir Tigunsev, E. G. Kornetova, Nikolay A. Bokhan, Bob Wilffert, Anton Loonen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Hyperprolactinemia (HPRL) is considered to be a frequent and typical adverse drug reaction caused by antipsychotic medications first and foremost due to excessive dopamine D2 receptors blockade. The aim is to study the set of polymorphisms of genes encoding neurotransmitter synthesis and metabolism enzymes COMT, TPH1 and TPH2 in schizophrenia inpatients. A comprehensive examination of 446 schizophrenia inpatients, aged 18-75 years, was conducted. Genotyping of DNA samples in patients with or without HPRL was carried out for 14 polymorphisms of COMT, TPH1, and TPH2 genes. We revealed an association between carriership of the COMT rs165774* G allele and HPRL. As a result of the study, a regression model was designed to predict the risk of developing HPRL in schizophrenia inpatients, taking into account age, gender, and treatment duration, the dosage of drugs in chlorpromazine equivalents as independent covariates and genotypes of the studied polymorphisms.

Original language	English
Title of host publication	2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB)
Publisher	IEEE
Pages	80-84
Number of pages	5
ISBN (Electronic)	978-1-7281-9597-1
ISBN (Print)	978-1-7281-9598-8
DOIs	https://doi.org/10.1109/CSGB51356.2020.9214668
Publication status	Published - 7-Oct-2020
Event	2020 Cognitive Sciences, Genomics and Bioinformatics - Novosibirsk, Russian Federation Duration: 6-Jul-2020 → 10-Jul-2020

Conference

Conference	2020 Cognitive Sciences, Genomics and Bioinformatics
Abbreviated title	CSGB
Country/Territory	Russian Federation
City	Novosibirsk
Period	06/07/2020 → 10/07/2020

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COMT gene polymorphism and antipsychotic- induced hyperprolactinemia in schizophrenia patientsFinal publisher's version, 226 KBLicence: Taverne

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Ivanova (Svetlana Ivanova), S. A., Paderina, D. Z., Boiko, A. S., Fedorenko, O., Pozhidaev, I. V., Tigunsev, V., Kornetova, E. G., Bokhan, N. A., Wilffert, B., & Loonen, A. (2020). COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients. In 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB) (pp. 80-84). IEEE. https://doi.org/10.1109/CSGB51356.2020.9214668

@inproceedings{1b9691ca76044a7583b42641a94280a4,

title = "COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients",

abstract = "Hyperprolactinemia (HPRL) is considered to be a frequent and typical adverse drug reaction caused by antipsychotic medications first and foremost due to excessive dopamine D2 receptors blockade. The aim is to study the set of polymorphisms of genes encoding neurotransmitter synthesis and metabolism enzymes COMT, TPH1 and TPH2 in schizophrenia inpatients. A comprehensive examination of 446 schizophrenia inpatients, aged 18-75 years, was conducted. Genotyping of DNA samples in patients with or without HPRL was carried out for 14 polymorphisms of COMT, TPH1, and TPH2 genes. We revealed an association between carriership of the COMT rs165774* G allele and HPRL. As a result of the study, a regression model was designed to predict the risk of developing HPRL in schizophrenia inpatients, taking into account age, gender, and treatment duration, the dosage of drugs in chlorpromazine equivalents as independent covariates and genotypes of the studied polymorphisms.",

author = "{Ivanova (Svetlana Ivanova)}, S.A. and Paderina, {Diana Z.} and Boiko, {Anastasiia S} and O. Fedorenko and Pozhidaev, {Ivan V} and Vladimir Tigunsev and Kornetova, {E. G.} and Bokhan, {Nikolay A.} and Bob Wilffert and Anton Loonen",

year = "2020",

month = oct,

day = "7",

doi = "10.1109/CSGB51356.2020.9214668",

language = "English",

isbn = "978-1-7281-9598-8",

pages = "80--84",

booktitle = "2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB)",

publisher = "IEEE",

note = "2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB ; Conference date: 06-07-2020 Through 10-07-2020",

}

Ivanova (Svetlana Ivanova), SA, Paderina, DZ, Boiko, AS, Fedorenko, O, Pozhidaev, IV, Tigunsev, V, Kornetova, EG, Bokhan, NA, Wilffert, B & Loonen, A 2020, COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients. in 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, pp. 80-84, 2020 Cognitive Sciences, Genomics and Bioinformatics, Novosibirsk, Russian Federation, 06/07/2020. https://doi.org/10.1109/CSGB51356.2020.9214668

COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients. / Ivanova (Svetlana Ivanova), S.A.; Paderina, Diana Z.; Boiko, Anastasiia S et al.
2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, 2020. p. 80-84.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients

AU - Ivanova (Svetlana Ivanova), S.A.

AU - Paderina, Diana Z.

AU - Boiko, Anastasiia S

AU - Fedorenko, O.

AU - Pozhidaev, Ivan V

AU - Tigunsev, Vladimir

AU - Kornetova, E. G.

AU - Bokhan, Nikolay A.

AU - Wilffert, Bob

AU - Loonen, Anton

PY - 2020/10/7

Y1 - 2020/10/7

N2 - Hyperprolactinemia (HPRL) is considered to be a frequent and typical adverse drug reaction caused by antipsychotic medications first and foremost due to excessive dopamine D2 receptors blockade. The aim is to study the set of polymorphisms of genes encoding neurotransmitter synthesis and metabolism enzymes COMT, TPH1 and TPH2 in schizophrenia inpatients. A comprehensive examination of 446 schizophrenia inpatients, aged 18-75 years, was conducted. Genotyping of DNA samples in patients with or without HPRL was carried out for 14 polymorphisms of COMT, TPH1, and TPH2 genes. We revealed an association between carriership of the COMT rs165774* G allele and HPRL. As a result of the study, a regression model was designed to predict the risk of developing HPRL in schizophrenia inpatients, taking into account age, gender, and treatment duration, the dosage of drugs in chlorpromazine equivalents as independent covariates and genotypes of the studied polymorphisms.

AB - Hyperprolactinemia (HPRL) is considered to be a frequent and typical adverse drug reaction caused by antipsychotic medications first and foremost due to excessive dopamine D2 receptors blockade. The aim is to study the set of polymorphisms of genes encoding neurotransmitter synthesis and metabolism enzymes COMT, TPH1 and TPH2 in schizophrenia inpatients. A comprehensive examination of 446 schizophrenia inpatients, aged 18-75 years, was conducted. Genotyping of DNA samples in patients with or without HPRL was carried out for 14 polymorphisms of COMT, TPH1, and TPH2 genes. We revealed an association between carriership of the COMT rs165774* G allele and HPRL. As a result of the study, a regression model was designed to predict the risk of developing HPRL in schizophrenia inpatients, taking into account age, gender, and treatment duration, the dosage of drugs in chlorpromazine equivalents as independent covariates and genotypes of the studied polymorphisms.

U2 - 10.1109/CSGB51356.2020.9214668

DO - 10.1109/CSGB51356.2020.9214668

M3 - Conference contribution

SN - 978-1-7281-9598-8

SP - 80

EP - 84

BT - 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB)

PB - IEEE

T2 - 2020 Cognitive Sciences, Genomics and Bioinformatics

Y2 - 6 July 2020 through 10 July 2020

ER -

COMT gene polymorphism and antipsychotic-induced hyperprolactinemia in schizophrenia patients

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