Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment

Jan F. Nauta, Yoran M. Hummel, Jasper Tromp, Wouter Ouwerkerk, Peter van der Meer, Xuanyi Jin, Carolyn S. P. Lam, Jeroen J. Bax, Marco Metra, Nilesh J. Samani, Piotr Ponikowski, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Leong L. Ng, Faiez Zannad, Gerasimos S. Filippatos, Dirk J. van Veldhuisen, Joost P. van Melle, Adriaan A. Voors*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


Aims Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy. Methods and results We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF

Original languageEnglish
Number of pages9
JournalEuropean Journal of Heart Failure
Publication statusE-pub ahead of print - 11-Nov-2019


  • Heart failure
  • Heart failure with reduced ejection fraction
  • Echocardiography
  • Left ventricular geometry
  • Concentric hypertrophy
  • Eccentric hypertrophy
  • Medical therapy
  • Biomarkers

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