Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment

Jan F. Nauta; Yoran M. Hummel; Jasper Tromp; Wouter Ouwerkerk; Peter van der Meer; Xuanyi Jin; Carolyn S. P. Lam; Jeroen J. Bax; Marco Metra; Nilesh J. Samani; Piotr Ponikowski; Kenneth Dickstein; Stefan D. Anker; Chim C. Lang; Leong L. Ng; Faiez Zannad; Gerasimos S. Filippatos; Dirk J. van Veldhuisen; Joost P. van Melle; Adriaan A. Voors

doi:10.1002/ejhf.1632

Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment

Jan F. Nauta, Yoran M. Hummel, Jasper Tromp, Wouter Ouwerkerk, Peter van der Meer, Xuanyi Jin, Carolyn S. P. Lam, Jeroen J. Bax, Marco Metra, Nilesh J. Samani, Piotr Ponikowski, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Leong L. Ng, Faiez Zannad, Gerasimos S. Filippatos, Dirk J. van Veldhuisen, Joost P. van Melle, Adriaan A. Voors^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Aims Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy. Methods and results We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF

Original language	English
Number of pages	9
Journal	European Journal of Heart Failure
DOIs	https://doi.org/10.1002/ejhf.1632
Publication status	E-pub ahead of print - 11-Nov-2019

Keywords

Heart failure
Heart failure with reduced ejection fraction
Echocardiography
Left ventricular geometry
Concentric hypertrophy
Eccentric hypertrophy
Medical therapy
Biomarkers
ASSOCIATION
MECHANISMS
MODELS

Access to Document

10.1002/ejhf.1632

Embargoed Document

Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction
Final publisher's version, 1.39 MB
Request copy

Cite this

Nauta, J. F., Hummel, Y. M., Tromp, J., Ouwerkerk, W., van der Meer, P., Jin, X., Lam, C. S. P., Bax, J. J., Metra, M., Samani, N. J., Ponikowski, P., Dickstein, K., Anker, S. D., Lang, C. C., Ng, L. L., Zannad, F., Filippatos, G. S., van Veldhuisen, D. J., van Melle, J. P., & Voors, A. A. (2019). Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1632

Nauta, Jan F. ; Hummel, Yoran M. ; Tromp, Jasper ; Ouwerkerk, Wouter ; van der Meer, Peter ; Jin, Xuanyi ; Lam, Carolyn S. P. ; Bax, Jeroen J. ; Metra, Marco ; Samani, Nilesh J. ; Ponikowski, Piotr ; Dickstein, Kenneth ; Anker, Stefan D. ; Lang, Chim C. ; Ng, Leong L. ; Zannad, Faiez ; Filippatos, Gerasimos S. ; van Veldhuisen, Dirk J. ; van Melle, Joost P. ; Voors, Adriaan A. / Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction : clinical characteristics, pathophysiology and response to treatment. In: European Journal of Heart Failure. 2019.

@article{9d6c69f73be3452388d8b2b344b60fe0,

title = "Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment",

abstract = "Aims Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy. Methods and results We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF",

keywords = "Heart failure, Heart failure with reduced ejection fraction, Echocardiography, Left ventricular geometry, Concentric hypertrophy, Eccentric hypertrophy, Medical therapy, Biomarkers, ASSOCIATION, MECHANISMS, MODELS",

author = "Nauta, {Jan F.} and Hummel, {Yoran M.} and Jasper Tromp and Wouter Ouwerkerk and {van der Meer}, Peter and Xuanyi Jin and Lam, {Carolyn S. P.} and Bax, {Jeroen J.} and Marco Metra and Samani, {Nilesh J.} and Piotr Ponikowski and Kenneth Dickstein and Anker, {Stefan D.} and Lang, {Chim C.} and Ng, {Leong L.} and Faiez Zannad and Filippatos, {Gerasimos S.} and {van Veldhuisen}, {Dirk J.} and {van Melle}, {Joost P.} and Voors, {Adriaan A.}",

year = "2019",

month = nov,

day = "11",

doi = "10.1002/ejhf.1632",

language = "English",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Wiley",

}

Nauta, JF, Hummel, YM, Tromp, J, Ouwerkerk, W, van der Meer, P, Jin, X, Lam, CSP, Bax, JJ, Metra, M, Samani, NJ, Ponikowski, P, Dickstein, K, Anker, SD, Lang, CC, Ng, LL, Zannad, F, Filippatos, GS, van Veldhuisen, DJ , van Melle, JP & Voors, AA 2019, 'Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment', European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1632

Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction : clinical characteristics, pathophysiology and response to treatment. / Nauta, Jan F.; Hummel, Yoran M.; Tromp, Jasper; Ouwerkerk, Wouter; van der Meer, Peter; Jin, Xuanyi; Lam, Carolyn S. P.; Bax, Jeroen J.; Metra, Marco; Samani, Nilesh J.; Ponikowski, Piotr; Dickstein, Kenneth; Anker, Stefan D.; Lang, Chim C.; Ng, Leong L.; Zannad, Faiez; Filippatos, Gerasimos S.; van Veldhuisen, Dirk J.; van Melle, Joost P.; Voors, Adriaan A.

In: European Journal of Heart Failure, 11.11.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction

T2 - clinical characteristics, pathophysiology and response to treatment

AU - Nauta, Jan F.

AU - Hummel, Yoran M.

AU - Tromp, Jasper

AU - Ouwerkerk, Wouter

AU - van der Meer, Peter

AU - Jin, Xuanyi

AU - Lam, Carolyn S. P.

AU - Bax, Jeroen J.

AU - Metra, Marco

AU - Samani, Nilesh J.

AU - Ponikowski, Piotr

AU - Dickstein, Kenneth

AU - Anker, Stefan D.

AU - Lang, Chim C.

AU - Ng, Leong L.

AU - Zannad, Faiez

AU - Filippatos, Gerasimos S.

AU - van Veldhuisen, Dirk J.

AU - van Melle, Joost P.

AU - Voors, Adriaan A.

PY - 2019/11/11

Y1 - 2019/11/11

N2 - Aims Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy. Methods and results We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF

AB - Aims Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy. Methods and results We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF

KW - Heart failure

KW - Heart failure with reduced ejection fraction

KW - Echocardiography

KW - Left ventricular geometry

KW - Concentric hypertrophy

KW - Eccentric hypertrophy

KW - Medical therapy

KW - Biomarkers

KW - ASSOCIATION

KW - MECHANISMS

KW - MODELS

U2 - 10.1002/ejhf.1632

DO - 10.1002/ejhf.1632

M3 - Article

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

ER -