Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

Sathidpak Nantasanti, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    39 Citations (Scopus)
    467 Downloads (Pure)

    Abstract

    Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, disease modeling, drug testing, and transplantation. In this review, we summarize the applications of liver-derived organoids and discuss their potential. It is likely that organoids will provide an invaluable tool to unravel disease mechanisms, design novel (personalized) treatment strategies, and generate autologous stem cells for gene editing and transplantation purposes.

    Original languageEnglish
    Pages (from-to)325-330
    Number of pages6
    JournalStem Cells Translational Medicine
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - Mar-2016

    Keywords

    • Organoids
    • Liver
    • Adult stem cell culture
    • Applications
    • HEPATITIS-C-VIRUS
    • LONG-TERM CULTURE
    • IN-VITRO EXPANSION
    • HEPATOCYTE TRANSPLANTATION
    • PROGENITOR CELLS
    • CYSTIC-FIBROSIS
    • FATTY LIVER
    • STEM-CELLS
    • INTESTINAL ORGANOIDS
    • B-VIRUS

    Cite this