In a large Dutch family with keratosis follicularis spinulosa decalvans (KFSD, MIM 308800), DNA linkage analysis was performed in order to locate the gene. Pedigree analysis and lod score calculation confirmed X-linked inheritance and revealed significant linkage to DNA markers on Xp. A maximum lod score of 5.70 at THETA = 0.0 was obtained with DXS41 (p99.6). The KFSD gene is tentatively located on Xp21.2-p22.2.
- KERATOSIS-FOLLICULARIS-SPINULOSA DECALVANS
- GENE MAPPING
- X-LINKED INHERITANCE
- CARRIER DETECTION
- CORNEA DEGENERATION