Abstract
Objective: To study whether specific congenital anomalies occur more often with a history of subfertility and/or the use of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
Design: Case-only analyses.
Setting: Not applicable.
Patient(s): We included live births, stillbirths, and terminated pregnancies with congenital anomalies without a known cause that had a birth year between 1997 and 2010 (n = 4,525). A total of 4,185 malformed cases were born to fertile couples and 340 to subfertile couples, of whom 139 had conceived after IVF/ICSI and 201 had conceived naturally after >12 months.
Intervention(s): None.
Main Outcome Measure(s): The contribution, expressed in odds ratios (ORs), of a history of subfertility and IVF/ICSI to each specific type of congenital anomaly, imprinting disorder, and syndromal disorder.
Result(s): We found subfertility to be associated with an increase in abdominal wall defects (adjusted OR [aOR] 2.43, 95% CI 1.05-5.62), penoscrotal hypospadia (aOR 9.83, 95% CI 3.58-27.04), right ventricular outflow tract obstruction (aOR 1.77, 95% CI 1.06-2.97), and methylation defects causing imprinting disorders (aOR 13.49, 95% CI 2.93-62.06). In vitro fertilization/ICSI was associated with an increased risk of polydactyly (OR 4.83, 95% CI 1.39-16.77) and more specifically polydactyly of the hands (OR 5.02, 95% CI 1.43-17.65).
Conclusion(s): In our registry-based study, parental subfertility was associated with an increase in abdominal wall defects, penoscrotal hypospadia, right ventricular outflow tract obstruction, and methylation defects causing imprinting disorders. In vitro fertilization/ICSI was associated with an increase in polydactyly, mainly of the hands. (C) 2015 by American Society for Reproductive Medicine.
Original language | English |
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Pages (from-to) | 1001-1010.e3 |
Number of pages | 13 |
Journal | Fertility and sterility |
Volume | 103 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr-2015 |
Keywords
- In vitro fertilization
- assisted reproductive technology
- subfertility
- congenital anomalies
- birth defects
- IN-VITRO FERTILIZATION
- ASSISTED REPRODUCTIVE TECHNOLOGY
- INTRACYTOPLASMIC SPERM INJECTION
- MAJOR BIRTH-DEFECTS
- HEART-DEFECTS
- INCREASED RISK
- INFANTS BORN
- MALFORMATIONS
- COHORT
- METAANALYSIS
Datasets
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EUROCAT Northern Netherlands
van Kammen-Bergman, J. (Creator), de Walle, H. (Creator), Bakker, M. (Creator), Lutke, R. (Creator), Siemensma-Mühlenberg, N. (Creator), Siemensma-Mühlenberg, N. (Creator), Zetstra-van der Woude, P. (Creator) & Doornbos, F. (Creator), University of Groningen, 1981
https://www.umcg.nl/NL/Zorg/ouders/Deelname_wetenschappelijk_onderzoek/OnderzoekNaarAangeborenAandoeningen/Paginas/default.aspx and one more link, https://www.umcg.nl/SiteCollectionDocuments/Zorg/Ouders/Eurocat/Registry_description_NNL_final_version_jan2018.pdf (show fewer)
Dataset