Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis

Diana Spierings; Gavin McStay; Maya Saleh; Cheryl Bender; Jerry Chipuk; Uli Maurer; Douglas R Green

doi:10.1126/science.1117105

Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis

Diana Spierings
, Gavin McStay
, Maya Saleh
, Cheryl Bender
, Jerry Chipuk
, Uli Maurer
, Douglas R Green

Research output: Contribution to journal › Article › Academic › peer-review

265 Citations (Scopus)

Abstract

The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. "Upstairs" of this event are the Bcl-2 family proteins that regulate and mediate MOMP; "downstairs" is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring "upstairs" of MOMP.

Original language	English
Pages (from-to)	66-67
Number of pages	2
Journal	Science
Volume	310
Issue number	5745
DOIs	https://doi.org/10.1126/science.1117105
Publication status	Published - 7-Oct-2005

Keywords

Animals
Apoptosis
Apoptotic Protease-Activating Factor 1
Caspases/metabolism
Cytochromes c/metabolism
Cytosol/metabolism
Inhibitor of Apoptosis Proteins
Intracellular Membranes/metabolism
Mitochondria/metabolism
Models, Biological
Permeability
Proteins/metabolism
Proto-Oncogene Proteins c-bcl-2/metabolism
Signal Transduction

Access to Document

10.1126/science.1117105

Handle.net

Persistent link

Embargoed Document

Connected to Death
Final publisher's version, 278 KB
Request copy

Cite this

@article{df61533c0773463993b6044e92b60580,

title = "Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis",

abstract = "The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. {"}Upstairs{"} of this event are the Bcl-2 family proteins that regulate and mediate MOMP; {"}downstairs{"} is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring {"}upstairs{"} of MOMP.",

keywords = "Animals, Apoptosis, Apoptotic Protease-Activating Factor 1, Caspases/metabolism, Cytochromes c/metabolism, Cytosol/metabolism, Inhibitor of Apoptosis Proteins, Intracellular Membranes/metabolism, Mitochondria/metabolism, Models, Biological, Permeability, Proteins/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, Signal Transduction",

author = "Diana Spierings and Gavin McStay and Maya Saleh and Cheryl Bender and Jerry Chipuk and Uli Maurer and Green, \{Douglas R\}",

year = "2005",

month = oct,

day = "7",

doi = "10.1126/science.1117105",

language = "English",

volume = "310",

pages = "66--67",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "5745",

}

TY - JOUR

T1 - Connected to death

T2 - the (unexpurgated) mitochondrial pathway of apoptosis

AU - Spierings, Diana

AU - McStay, Gavin

AU - Saleh, Maya

AU - Bender, Cheryl

AU - Chipuk, Jerry

AU - Maurer, Uli

AU - Green, Douglas R

PY - 2005/10/7

Y1 - 2005/10/7

N2 - The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. "Upstairs" of this event are the Bcl-2 family proteins that regulate and mediate MOMP; "downstairs" is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring "upstairs" of MOMP.

AB - The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. "Upstairs" of this event are the Bcl-2 family proteins that regulate and mediate MOMP; "downstairs" is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring "upstairs" of MOMP.

KW - Animals

KW - Apoptosis

KW - Apoptotic Protease-Activating Factor 1

KW - Caspases/metabolism

KW - Cytochromes c/metabolism

KW - Cytosol/metabolism

KW - Inhibitor of Apoptosis Proteins

KW - Intracellular Membranes/metabolism

KW - Mitochondria/metabolism

KW - Models, Biological

KW - Permeability

KW - Proteins/metabolism

KW - Proto-Oncogene Proteins c-bcl-2/metabolism

KW - Signal Transduction

U2 - 10.1126/science.1117105

DO - 10.1126/science.1117105

M3 - Article

C2 - 16210526

SN - 0036-8075

VL - 310

SP - 66

EP - 67

JO - Science

JF - Science

IS - 5745

ER -

Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis

Abstract

Keywords

Access to Document

Handle.net

Embargoed Document

Fingerprint

Cite this