Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis

Hein Schepers; B.J.L. Eggen; Jan-Jacob Schuringa; Edo Vellenga

Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis

Hein Schepers, B.J.L. Eggen, Jan-Jacob Schuringa, Edo Vellenga^*

^*Corresponding author for this work

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Abstract

Since nuclear factor-κB (NF-κB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-κB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-κB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-κB activation was not sufficient to induce changes in stem- and progenitor cell numbers.

Original language	English
Pages (from-to)	1710-1711
Number of pages	2
Journal	Haematologica-the Hematology Journal
Volume	91
Issue number	12
Publication status	Published - 2006

Keywords

NF-kappa B
IKK2
differentiation
proliferation
leukemia
PROTEINS
CELLS
AML

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title = "Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis",

abstract = "Since nuclear factor-κB (NF-κB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-κB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-κB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-κB activation was not sufficient to induce changes in stem- and progenitor cell numbers.",

keywords = "NF-kappa B, IKK2, differentiation, proliferation, leukemia, PROTEINS, CELLS, AML",

author = "Hein Schepers and B.J.L. Eggen and Jan-Jacob Schuringa and Edo Vellenga",

note = "Relation: http://www.rug.nl/gbb/ date_submitted:2007 Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute",

year = "2006",

language = "English",

volume = "91",

pages = "1710--1711",

journal = "Haematologica-the Hematology Journal",

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TY - JOUR

T1 - Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis

AU - Schepers, Hein

AU - Eggen, B.J.L.

AU - Schuringa, Jan-Jacob

AU - Vellenga, Edo

N1 - Relation: http://www.rug.nl/gbb/ date_submitted:2007 Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute

PY - 2006

Y1 - 2006

N2 - Since nuclear factor-κB (NF-κB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-κB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-κB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-κB activation was not sufficient to induce changes in stem- and progenitor cell numbers.

AB - Since nuclear factor-κB (NF-κB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-κB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-κB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-κB activation was not sufficient to induce changes in stem- and progenitor cell numbers.

KW - NF-kappa B

KW - IKK2

KW - differentiation

KW - proliferation

KW - leukemia

KW - PROTEINS

KW - CELLS

KW - AML

M3 - Article

SN - 0390-6078

VL - 91

SP - 1710

EP - 1711

JO - Haematologica-the Hematology Journal

JF - Haematologica-the Hematology Journal

IS - 12

ER -

Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis

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Keywords

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