TY - JOUR
T1 - Contact Allergy in Children in Europe
T2 - A Proposal for a Paediatric European Baseline Series
AU - the European Baseline Series (EBS) Working Party of the European Society of Contact Dermatitis (ESCD)
AU - Simonsen, Anne Birgitte
AU - Rustemeyer, Thomas
AU - Hadzavdic, Suzana Ljubojevicé
AU - Spiewak, Radoslaw
AU - Fortina, Anna Belloni
AU - Gonçalo, Margarida
AU - Arnau, Ana Maria Giménez
AU - Planella-Fontanillas, Nidia
AU - Schuttelaar, Marie L.A.
AU - Dickel, Heinrich
AU - White, Jonathan
AU - Pónyai, Györgyi
AU - Wilkinson, S. Mark
AU - Özkaya, Esen
AU - Dendooven, Ella
AU - Pustišek, Nives
AU - Johansen, Jeanne Duus
AU - Aerts, Olivier
N1 - Publisher Copyright:
© 2025 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd.
PY - 2025/9/19
Y1 - 2025/9/19
N2 - Background: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.Objectives: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.Materials and Methods: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0–16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.Results: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.Conclusion: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.
AB - Background: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.Objectives: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.Materials and Methods: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0–16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.Results: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.Conclusion: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.
KW - baseline series
KW - children
KW - contact allergens
KW - patch testing
UR - https://www.scopus.com/pages/publications/105018109825
U2 - 10.1111/cod.70033
DO - 10.1111/cod.70033
M3 - Article
C2 - 40973997
AN - SCOPUS:105018109825
SN - 0105-1873
JO - Contact Dermatitis
JF - Contact Dermatitis
ER -