Contact allergy in children with and without atopic dermatitis; which are the frequent allergens?

S. Lubbes, T. Rustemeyer, M.L.A. Schuttelaar, J.H. Sillevis Smitt, M.A. Middelkamp-Hup

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Background: Data on contact allergies in children are poor. This study aims to identify the occurrence of contact allergies and relevance of allergens in children. This will allow better identification of potential sensitizers and improve patients' care in children. Patients and methods: We retrospectively analyzed data of children aged 0-18 years, that were patchtested with at least the European base line series between 1996-2013 in 3 University Hospitals across the Netherlands. Patchtesting was performed using the TRUE-test (n=322) and Trolab/Hermal/ Chemotechnique allergens (n=690). Additional patch tests series were also analyzed. Preliminary results: 1012 Children (male 38%, mean age 13 years) were included, of which 531 (52%) developed ≥1 positive reaction. The most frequent reactions were found to nickel (16,4%: 164/998), cocamidopropylbetaine (15,9%: 54/339), Fragrancemix-I (9,8%: 99/1008), amerchol-L-101 (8,8%: 30/339) and woolalcohols (6,1%: 62/1009). In children with atopic dermatitis (AD) the most common reaction was to cocamidopropylbetaine, although this difference was not significant compared to children without AD. Reactions to woolalcohols were significantly more common in children with AD (p=0,04). Strikingly, significantly less positive reactions to woolalcohols were found testing with the TRUE-test (n=4) compared to testing with Trolab/Hermal/Chemotechnique patchtest preparations (n=55) (p
Original languageEnglish
Pages (from-to)39-40
Number of pages2
JournalNederlands Tijdschrift voor Dermatologie en Venereologie
Issue number1
Publication statusPublished - 1-Jan-2014


  • allergen
  • amerchol l 101
  • nickel
  • child
  • human
  • atopic dermatitis
  • contact allergy
  • population
  • patient
  • patch test
  • Netherlands
  • university hospital
  • contact dermatitis
  • male
  • sensitization

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