Contribution of chronic disease to the burden of disability.

Abstract
Background: Population ageing is expected to lead to strong increases in the number of persons with one or more
disabilities, which may result in substantial declines in the quality of life. To reduce the burden of disability and to prevent
concomitant declines in the quality of life, one of the first steps is to establish which diseases contribute most to the burden.
Therefore, this paper aims to determine the contribution of specific diseases to the prevalence of disability and to years
lived with disability, and to assess whether large contributions are due to a high disease prevalence or a high disabling
impact.
Methodology/Principal Findings: Data from the Dutch POLS-survey (Permanent Onderzoek Leefsituatie, 2001–2007) were
analyzed. Using additive regression and accounting for co-morbidity, the disabling impact of selected chronic diseases was
calculated, and the prevalence and years lived with ADL and mobility disabilities were partitioned into contributions of
specific disease. Musculoskeletal and cardiovascular disease contributed most to the burden of disability, but chronic nonspecific
lung disease (males) and diabetes (females) also contributed much. Within the musculoskeletal and cardiovascular
disease groups, back pain, peripheral vascular disease and stroke contributed particularly by their high disabling impact.
Arthritis and heart disease were less disabling but contributed substantially because of their high prevalence. The disabling
impact of diseases was particularly high among persons older than 80.
Conclusions/Significance: To reduce the burden of disability, the extent diseases such as back pain, peripheral vascular
disease and stroke lead to disability should be reduced, particularly among the oldest old. But also moderately disabling
diseases with a high prevalence, such as arthritis and heart disease, should be targeted.