Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

M Abdullah Said, Yordi J van de Vegte, Muhammad Mobeen Zafar, M Yldau van der Ende, Ghazala Kaukab Raja, N Verweij, Pim van der Harst

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
79 Downloads (Pure)

Abstract

PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.

RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.

Original languageEnglish
Article number89
Pages (from-to)89
Number of pages8
JournalCurrent cardiology reports
Volume21
Issue number9
DOIs
Publication statusPublished - Sep-2019

Keywords

  • Genetics
  • Lifestyle
  • Coronary artery disease
  • Genetic lifestyle interactions
  • Genome-wide association studies
  • Genetic risk scores
  • DOSE-RESPONSE METAANALYSIS
  • TERM COFFEE CONSUMPTION
  • HEART-DISEASE
  • CARDIOVASCULAR-DISEASE
  • PHYSICAL-ACTIVITY
  • MYOCARDIAL-INFARCTION
  • ALCOHOL-CONSUMPTION
  • CIGARETTE-SMOKING
  • ASSOCIATION
  • INDIVIDUALS

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