Control of autophagy in parkinson’s disease

Rosa A. González-Polo; Rubén Gómez-Sánchez; Elisa Pizarro-Estrella; Sokhna M.S. Yakhine-Diop; Mario Rodríguez-Arribas; José M. Fuentes

doi:10.1007/978-3-319-13939-5_6

Control of autophagy in parkinson’s disease

Rosa A. González-Polo, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Sokhna M.S. Yakhine-Diop, Mario Rodríguez-Arribas, José M. Fuentes

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

1 Citation (Scopus)

Abstract

© Springer International Publishing Switzerland 2015. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a dysregulation of cellular degradation system. An accumulation of misfolded proteins has been founded in the brains of parkinsonian patients, causing neuroinflammation and oxidative stress, and leading to a progressive neurodegeneration. Autophagy plays an important role in the progression of PD. In this chapter, we analyze the relationship of different types of autophagy (microautophagy, chaperone- mediated autophagy (CMA) and macroautophagy) with the oxidative stress and with several proteins involved in PD, showing deregulation of these degradative processes when these proteins are mutated. Also, we show a possible therapeutic alternative based on autophagy inducers that might be a potential drug for PD treatment.

Original language	English
Title of host publication	Toxicity and Autophagy in Neurodegenerative Disorders
Publisher	Springer International Publishing AG
Pages	91-122
Number of pages	32
ISBN (Print)	9783319139395
DOIs	https://doi.org/10.1007/978-3-319-13939-5_6
Publication status	Published - 1-Jan-2015
Externally published	Yes

Publication series

Name	Toxicity and Autophagy in Neurodegenerative Disorders

Keywords

Autophagy
Neurotoxicity
PARK genes
Parkinson’s disease
Pesticides

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10.1007/978-3-319-13939-5_6

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González-Polo, R. A., Gómez-Sánchez, R., Pizarro-Estrella, E., Yakhine-Diop, S. M. S., Rodríguez-Arribas, M., & Fuentes, J. M. (2015). Control of autophagy in parkinson’s disease. In Toxicity and Autophagy in Neurodegenerative Disorders (pp. 91-122). (Toxicity and Autophagy in Neurodegenerative Disorders). Springer International Publishing AG. https://doi.org/10.1007/978-3-319-13939-5_6

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abstract = "{\textcopyright} Springer International Publishing Switzerland 2015. Parkinson{\textquoteright}s disease (PD) is a neurodegenerative disorder characterized by a dysregulation of cellular degradation system. An accumulation of misfolded proteins has been founded in the brains of parkinsonian patients, causing neuroinflammation and oxidative stress, and leading to a progressive neurodegeneration. Autophagy plays an important role in the progression of PD. In this chapter, we analyze the relationship of different types of autophagy (microautophagy, chaperone- mediated autophagy (CMA) and macroautophagy) with the oxidative stress and with several proteins involved in PD, showing deregulation of these degradative processes when these proteins are mutated. Also, we show a possible therapeutic alternative based on autophagy inducers that might be a potential drug for PD treatment.",

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author = "Gonz{\'a}lez-Polo, {Rosa A.} and Rub{\'e}n G{\'o}mez-S{\'a}nchez and Elisa Pizarro-Estrella and Yakhine-Diop, {Sokhna M.S.} and Mario Rodr{\'i}guez-Arribas and Fuentes, {Jos{\'e} M.}",

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doi = "10.1007/978-3-319-13939-5_6",

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González-Polo, RA, Gómez-Sánchez, R, Pizarro-Estrella, E, Yakhine-Diop, SMS, Rodríguez-Arribas, M & Fuentes, JM 2015, Control of autophagy in parkinson’s disease. in Toxicity and Autophagy in Neurodegenerative Disorders. Toxicity and Autophagy in Neurodegenerative Disorders, Springer International Publishing AG, pp. 91-122. https://doi.org/10.1007/978-3-319-13939-5_6

Control of autophagy in parkinson’s disease. / González-Polo, Rosa A.; Gómez-Sánchez, Rubén; Pizarro-Estrella, Elisa et al.
Toxicity and Autophagy in Neurodegenerative Disorders. Springer International Publishing AG, 2015. p. 91-122 (Toxicity and Autophagy in Neurodegenerative Disorders).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

TY - CHAP

T1 - Control of autophagy in parkinson’s disease

AU - González-Polo, Rosa A.

AU - Gómez-Sánchez, Rubén

AU - Pizarro-Estrella, Elisa

AU - Yakhine-Diop, Sokhna M.S.

AU - Rodríguez-Arribas, Mario

AU - Fuentes, José M.

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AB - © Springer International Publishing Switzerland 2015. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a dysregulation of cellular degradation system. An accumulation of misfolded proteins has been founded in the brains of parkinsonian patients, causing neuroinflammation and oxidative stress, and leading to a progressive neurodegeneration. Autophagy plays an important role in the progression of PD. In this chapter, we analyze the relationship of different types of autophagy (microautophagy, chaperone- mediated autophagy (CMA) and macroautophagy) with the oxidative stress and with several proteins involved in PD, showing deregulation of these degradative processes when these proteins are mutated. Also, we show a possible therapeutic alternative based on autophagy inducers that might be a potential drug for PD treatment.

KW - Autophagy

KW - Neurotoxicity

KW - PARK genes

KW - Parkinson’s disease

KW - Pesticides

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DO - 10.1007/978-3-319-13939-5_6

M3 - Chapter

SN - 9783319139395

T3 - Toxicity and Autophagy in Neurodegenerative Disorders

SP - 91

EP - 122

BT - Toxicity and Autophagy in Neurodegenerative Disorders

PB - Springer International Publishing AG

ER -

Control of autophagy in parkinson’s disease

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