Control of autophagy in parkinson’s disease

Rosa A. González-Polo, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Sokhna M.S. Yakhine-Diop, Mario Rodríguez-Arribas, José M. Fuentes

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)

Abstract

© Springer International Publishing Switzerland 2015. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a dysregulation of cellular degradation system. An accumulation of misfolded proteins has been founded in the brains of parkinsonian patients, causing neuroinflammation and oxidative stress, and leading to a progressive neurodegeneration. Autophagy plays an important role in the progression of PD. In this chapter, we analyze the relationship of different types of autophagy (microautophagy, chaperone- mediated autophagy (CMA) and macroautophagy) with the oxidative stress and with several proteins involved in PD, showing deregulation of these degradative processes when these proteins are mutated. Also, we show a possible therapeutic alternative based on autophagy inducers that might be a potential drug for PD treatment.
Original languageEnglish
Title of host publicationToxicity and Autophagy in Neurodegenerative Disorders
PublisherSpringer International Publishing AG
Pages91-122
Number of pages32
ISBN (Print)9783319139395
DOIs
Publication statusPublished - 1-Jan-2015
Externally publishedYes

Publication series

NameToxicity and Autophagy in Neurodegenerative Disorders

Keywords

  • Autophagy
  • Neurotoxicity
  • PARK genes
  • Parkinson’s disease
  • Pesticides

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